This chapter discusses the hormonal regulation of bone remodeling. Bone remodeling refers to the renewal process, whereby small pockets of old bone, dispersed throughout the skeleton and separated from others geographically as well as chronologically, are replaced by new bone throughout adult life. ...
“Bone remodeling” is a term used to describe the processes of removing dead bone (resorption by osteoclasts) and depositing new bone (formation by osteoblasts) for repairing bone damage. From: Basic Finite Element Method as Applied to Injury Biomechanics, 2018 ...
Coupling during bone remodeling refers to the spatial and temporal coordination of bone resorption with bone formation. Studies have assessed the subtle in... Beom-Jun,Kim,Jung-Min,... - 《Cellular & Molecular Life Sciences Cmls》 被引量: 0发表: 2019年 Osteoclast-derived apoptotic bodies couple...
Bone remodeling refers to a close coupling process of bone resorption and bone formation in time and space in bone metabolic activity. Bone remodeling is a... K Huang,H Hou,M Song,... - 《Chinese Journal of Osteoporosis》 被引量: 0发表: 2018年 bone-derived exosomes sciencedirect Bone rem...
To date, discussions of the “endosteal” niche have been largely focused on the osteogenic components. However, little emphasis has been directed to “dynamic remodeling”, which involves distinct stages of bone resorption, reversal, and deposition cycles. The cellular and molecular mechanisms that ...
In bone remodeling, osteoblast–osteoclast interactions are necessary and must be coordinated in time and space to maintain the focal bone remodeling balance; this balance refers to the net amount of tissue resorbed and formed at each remodeling site (i.e., focal point) to maintain the structural...
It further regulates bone remodeling by converting mechanical stimuli into biochemical signals to modulate the migration, proliferation, and differentiation of osteoblasts. Additionally, it is emerging as a potential novel therapeutic mechanosensor for bone healing process [9, 10]. However, it remains ...
Activation of bone remodeling primarily depends on osteoblast. Either on the bone surface or in the marrow, osteoblasts act on blood cell precursors to recruit, differentiate, and activate bone-resorbing osteoclasts. The resorption process may take place under a layer of lining cells. After the ...
bone remodeling, OC-mediated bone resorption creates space for nerve sprouting and promotes the innervation of nerves through the release of nerve inducing molecules, such as netrin 1 and NGF. The receptor activator of nuclear factor κB ligand (RANKL) on OBs can bind to RANK on OC precursors....
to 0.5% per year in both men and women. There is an accelerated loss of cortical bone superimposed on the age-related loss around the menopause in women. The cumulative losses of bone mass range from 20 to 30% in men and up to 50% in women. Remodeling activity is typically increased ...