This chapter discusses that the adult skeleton is in a dynamic state, being continually remodeled by the integrated processes of bone resorption and bone formation. The remodeling of bone occurs in focal or discrete packets throughout the skeleton, known as bone remodeling units or bone structural ...
Bone loss occurs as early as the third day of immobilization. Bone alterations induced by immobilization predispose the elderly patient to fractures of the hip, spine and extremities. The elderly are especially vulnerable because bone loss resulting from inactivity or limited mobility is compounded by...
bones suffer local microdamages; bone remodeling allows the reinstatement of such microdamages. According to low or high mechanical strains of the skeleton bunches of bones are removed or created, respectively. Coupling is referred as the common remodeling process...
Research suggests that before bone metastasis occurs, breast cancer cells can influence the bone microenvironment by secreting factors to create favorable conditions for metastasis. Factors derived from breast cancer cells, such as IL-1β, may drive bone metastasis by remodeling the bone microenvironment...
Paget’s disease usually occurs in adults over age 40. It is a disorder of the bone remodeling process that begins with overactive osteoclasts. This means more bone is resorbed than is laid down. The osteoblasts try to compensate but the new bone they lay down is weak and brittle and ther...
Research suggests that before bone metastasis occurs, breast cancer cells can influence the bone microenvironment by secreting factors to create favorable conditions for metastasis. Factors derived from breast cancer cells, such as IL-1β, may drive bone metastasis by remodeling the bone microenvironment...
Bone deposition occurs vertically, thus increasing the depth of the socket. The alveolar bone continues to remodel, filling in around the root as it erupts and lengthens. It is during this process that the true alveolar bone is created to provide support for the tooth. Ultimately, the crown ...
It occurs as a result of hematogenous dissemination through the portal vein-vertebral vein plexus that communicate in situations of portal vein thrombosis and/or portal hypertension [35]. Bone metastasis may be a site of symptomatic manifestation with pain occurring from tumor expansion within the ...
In young, healthy bone tissue, bone breakdown occurs continually as the result of osteoclast activity, but the breakdown is balanced by new bone formation by osteoblasts. In an elderly patient, bone resorption can surpass bone formation thus resulting in deterioration of bone density. Osteoporosis ...
but rather continuous remodeling of bone and metabolic maintenance of the various cells and proteins as they age and become nonfunctional. Bone is incompressible above or below its elastic limit, i.e., Young's Modulus. Poisson's ratio is used to describe this behavior and is defined as ...