In a cancer-free environment in the adult, the skeleton continuously undergoes remodeling. Bone-resorbing osteoclasts excavate erosion cavities, and bone-depositing osteoblasts synthesize osteoid matrix that forms new bone, with no net bone gain or loss. When metastatic breast cancer cells invade the ...
Additionally, it has recently been shown that, at prevailing calcium intakes, bone remodeling occurs at a rate considerably in excess of the need to repair fatigue damage (Heaney, 2003; Parfitt, 2004), and that this excess remodeling is a more important fracture risk factor than had been previ...
This chapter discusses that the adult skeleton is in a dynamic state, being continually remodeled by the integrated processes of bone resorption and bone formation. The remodeling of bone occurs in focal or discrete packets throughout the skeleton, known as bone remodeling units or bone structural ...
Research suggests that before bone metastasis occurs, breast cancer cells can influence the bone microenvironment by secreting factors to create favorable conditions for metastasis. Factors derived from breast cancer cells, such as IL-1β, may drive bone metastasis by remodeling the bone microenvironment...
Paget’s disease usually occurs in adults over age 40. It is a disorder of the bone remodeling process that begins with overactive osteoclasts. This means more bone is resorbed than is laid down. The osteoblasts try to compensate but the new bone they lay down is weak and brittle and ther...
Mesenchymal stem cells (MSCs) are a promising candidate for bone repair. However, the maintenance of MSCs injected into the bone injury site remains inefficient. A potential approach is to develop a bone-liked platform that incorporates MSCs into a bioco
pan, the reference being an empty sealed aluminium pan. Collagen purity is determined on the basis of thermal stability. Collagen solutions typically exhibit an endothermic peak around 40 °C, indicating denaturation into gelatine that occurs through the irreversible unfolding of the triple helix57....
in rather continuous blocks, many hundreds of micrometers in size, or may, as the result of the remodeling that occurs continually in bone, be arranged in tubular structures (secondary osteons, often called Haversian systems), of the order of 150μm in diameter with the concentric lamellae ...
The bone remodeling unit on trabecular bone surfaces can actually be viewed as a resorption channel in compact bone cut in half (compare Figures 6-33 and 6-35). This account indicates that a considerable amount of internal remodeling by means of resorption and deposition occurs within bone. ...
making the bone very fragile. In young, healthy bone tissue, bone breakdown occurs continually as the result of osteoclast activity, but the breakdown is balanced by new bone formation by osteoblasts. In an elderly patient, bone resorption can surpass bone formation thus resulting in deterioration ...