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In addition to a role in long-term barrier induction and maintenance, astrocytes and other cells can release chemical factors that modulate endothelial permeability over a time-scale of seconds to minutes. Cell culture models, both primary and cell lines, have been used to investigate aspects of ...
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In contrast, Src blockade for 2 to 6 days after thrombin injections is postulated to prevent resolution of edema and abnormal BBB permeability in part because Src kinase proto-oncogene members stimulate proliferation of newborn BMVECs and perivascular astrocytes in the neurovascular niche that repair ...
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Alterations in the ECM have a similar impact on the BBB permeability as disruptions of the cellular components favor increased leukocyte and macromolecular trafficking through a normally impermeable barrier [70]. 3. In Vitro Models of the Human Blood–Brain Barrier The obvious structural complexity of...
Consequently, harmful substances may pass through the barrier, causing toxins to accumulate in the brain while simultaneously releasing BBB-specific compounds that can serve as indicators of the pathological process in the BBB. Mild vascular cognitive impairment is related to increased BBB permeability, ...
Evaluation of Blood-Brain Barrier Integrity Using Vascular Permeability Markers: Evans Blue, Sodium Fluorescein, Albumin-Alexa Fluor Conjugates, and Horseradish Peroxidase. Methods Mol. Biol. 2021, 2367, 87–103. [Google Scholar] [PubMed] Saunders, N.R.; Dziegielewska, K.M.; Mollgard, K.;...
Despite some beneficial effects on cognition, the effects of n-3 PUFAs on the blood–brain barrier (BBB) are not clearly understood. We examined the effects of FFA1 activation on BBB permeability in vitro, using rat brain microvascular endothelial cells (RBMVEC), and in vivo, by assessing ...