Blood-Brain Barrier Permeabilization with Engineered Tumor Necrosis Factor-α Followed by R-CHOP Is an Active and Safe Salvage Therapy in Primary CNS LymphomaCNS tumoursprimary CNS lymphomablood-brain barriertumor necrosis factorchemoimmunotherapyBackground: R-CHOP is the standard treatment of diffuse ...
Multiple sclerosis is a human autoimmune disease caused by the induction of inflammation in the central nervous system (CNS) by myelin-specific T cells that cross the protective environment of the blood–brain barrier (BBB)1. The mouse model of multiple sclerosis, experimental autoimmune encephalomyel...
The blood–brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across the barrier means that most drugs, particularly large size, which includes powerful biologicals...
Drug delivery to the brain is challenging due to the restrict permeability of the blood brain barrier (BBB). Recent studies indicate that BBB permeability increases over time during physiological aging likely due to factors (including extracellular vesic
Blood–brain barrier muNEP: Mutated variant of neprilysin (G399V/G714K) NEP: Neprilysin scFc: Single-chain fragment constant scFv: Single-chain fragment variable sNEP: Soluble neprilysin Swe: Swedish APP mutation TfR: Transferrin receptor
Feasibility of blood–brain barrier opening using MRgFUS in the leg control region of the right primary motor cortex.aLeg control region mapping using motor-task functional MRI (fMRI).b,cshow confirmation of successful blood–brain barrier permeabilization in the sonicated primary motor cortex area...
to identify new possible drug targets that diminish/prevent BBB permeabilization in neurological and neurodegenerative disorders. View chapterExplore book Anatomy and physiology of blood-brain barrier SmritiGupta, ...RajatSandhir, inBrain Targeted Drug Delivery System, 2019...
The blood–brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across the barrier means that most drugs, particularl
A microfluidic model of the blood–brain barrier to study permeabilization by pulsed electric fields A microfluidic model of the blood-brain barrier to study permeabilization by pulsed electric fields. RSC Adv. 2017, 7, 42811-42818. [CrossRef] [PubMed]Bonakdar M, Graybill PM, Davalos RV. (...
N. et al. Medulloblastoma genotype dictates blood brain barrier phenotype. Cancer Cell 29, 508–522 (2016). Article CAS PubMed PubMed Central Google Scholar Connell, J. J. et al. Selective permeabilization of the bloodbrain barrier at sites of metastasis. J. Natl Cancer Inst. 105, 1634...