Novel blood-brain barrier permeant amyloid-targeting peptides and peptide conjugates are described. The peptide conjugates include a radioisotope or other label in a stable complex that translocates across brain capillary endothelial cell monolayers. The labeled peptide conjugate binds to amyloid plaques (...
NeuroRx: The Journal of the American Society for Experimental NeuroTherapeutics The Blood-Brain Barrier: Bottleneck in Brain Drug Development William M. Pardridge Department of Medicine, UCLA, Los Angeles, California 90024 Summary: The blood-brain barrier (BBB) is formed by the brain capillary ...
53 compounds with clinically established ability to cross or not to cross the blood-brain barrier by passive diffusion were characterized by means of surface activity measurements in terms of three parameters, i.e., the air-water partition coefficient, Kaw, the critical micelle concentration, CMCD,...
Brain glioma treatment with checkpoint inhibitor antibodies to cytotoxic T-lymphocyte-associated antigen 4 (a-CTLA-4) and programmed cell death-1 (a-PD-1) was largely unsuccessful due to their inability to cross blood–brain barrier (BBB). Here we descri
The blood–brain barrier (BBB) protects the central nervous system (CNS) from unregulated exposure to the blood and its contents. The BBB also controls the blood-to-brain and brain-to-blood permeation of many substances, resulting in nourishment of the CNS, its homeostatic regulation and communi...
Blood-BrainBarrierSep,20,2010Feisun Blood-BrainBarrierintroduction 2 WhatistheBloodBrainBarrier 3 BBBpermeationmechanisms 4 Restrictivephysicochemicalcharacteristics Phosphatidylserine 5 Higheffluxactivityanduptaketransport 6 Braindistributionmechanismsmechanismslimittheaccessofcompoundstobraincellsbyaffectingthedistributionof...
Blood-brain barrier(BBB) serves as an essential interface between central nervous system (CNS) and its periphery, allowing selective permeation of ions, gaseous molecules, and other nutrients to maintain metabolic functions of brain. Concurrently, it restricts passage of unsolicited materials from bloods...
Keywords: Alzheimer’s disease;chitosan oligosaccharides;blood-brain barrier;Aβ42;aggregation;binding affinity;cytotoxicity Graphical Abstract
Blood brain barrier− structure, molecular composition, and physiology. • Transportation across the blood-brain barrier. • Blood-brain barrier dysfunction andneurological disorders. • Criteria of drugs for blood-brain barrier permeation.
血脑屏障Blood-BrainBarrier Blood-BrainBarrierintroduction 2 WhatistheBloodBrainBarrier 3 Braindistributionmechanismsmechanismslimittheaccessofcompoundstobraincellsbyaffectingthedistributionofcompoundtoorwithinthebrain 7 Metabolicclearance 8 Plasmaproteinbinding 9 Bounddrugcanreleaseinbrainmicrovesselcirculation 10 Nonspec...