permeability, Blood–Brain Barrier (BBBpermeability data using endothelial cell models of BBBBBB, key element in CNS drug accessbiophysical analysis of in vitro endothelial cell modelsPAMPA–BBB, molecules affected by carrier‐mediated processThis chapter concludes the three-part permeability series, ...
Blood–brain barrier (BBB) permeability assessment remains of ongoing interest in clinical practice and research. Transitions between intravascular (IV) and extravascular (EV) gray matter (GM) compartments may provide information regarding the microstructural status of the BBB. Due to different transverse...
Blood–brain barrier (BBB) is a semi-permeable barrier encompassing microvasculature of central nervous system (CNS). In the capillaries, the wedged endothelial cells line in the interior vessels forming extensive tight junctions.1,2,3Together with an ensemble of receptors, transporters, efflux pumps...
2) blood-brain barrier(BBB) 血脑屏障 1. Objective:To investigate the properties of intestinal absorption and in vitro blood-brain barrier(BBB) permeability of liquirtigenin. 目的:研究甘草素(liquirtigenin)的肠吸收及血脑屏障(BBB)通透性。 2. Objective To examine the changes of tumor necrosis ...
A. Blood–brain barrier permeability in aging and Alzheimer's disease. J. Prev. Alzheimers Dis. 1, 138–139 (2014). PubMed PubMed Central CAS Google Scholar Hardy, J. & Allsop, D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol. Sci....
1.Objective:To investigate the properties of intestinal absorption and in vitro blood-brain barrier(BBB) permeability of liquirtigenin.目的:研究甘草素(liquirtigenin)的肠吸收及血脑屏障(BBB)通透性。 2.Objective To examine the changes of tumor necrosis factor-α(TNF-α) and circulating intercellular ...
15.5The Blood–Brain Barrier TheBBBis a critical interface. It acts as a physical and metabolic barrier between the CNS and the peripheral circulation that serves to regulate and protect the microenvironment of the brain. The primary function of the normal BBB is to establish and maintain homeosta...
InterpretingDataforBrainPenetrationThemostcommonlyusedbrainpenetrationdataisB/P;itslogisLogBB.B/P>0.3isusedasaminimumguidelineforCNSdiscoveryprojects.yetsomecommercialCNSdrugshaveB/P<0.1.B/Pisiscalculatedfromvariousdata:14 ThelimitationofB/P 15 Papp,PS,andt1/2eq.inIndicatetheRateofBBBPermeability 16 Eff...
Blood-brain barrier permeability in rats exposed to electromagnetic fields used in wireless communication 来自 dx.doi.org 喜欢 0 阅读量: 44 作者:BR Persson,LG Salford,A Brun 摘要: Biological effects of radio frequency electromagnetic fields (EMF) on the blood‐brain barrier (BBB) have been ...
Examination of blood-brain barrier (BBB) integrity in a mouse tumour model. J Neurooncol. 2013;111(2):133-143.Ngoc, O.; Mitchell, R.; Savant, S.D.; Bachmeier, C.J.; Hatch, G.M.; Miller, D.W. Examination of blood-brain barrier (BBB) integrity in a mouse brain tumour model. ...