The effects of LG283 were also examined in a bleomycin-induced skin fibrosis mouse model. Results:LG283 suppressed TGF-β-induced expression of ECM, α-SMA, and transcription factors Snail 1 and 2, and Smad3 phosphorylation in cultured human dermal fibroblasts. LG283 was also found to block ...
Here, we found that GSDMD was significantly up-regulated and activated in the skin of scleroderma patients and bleomycin-induced mouse model. What’s more, the ablation of GSDMD ameliorates bleomycin-induced skin fibrosis according to HE staining, Masson staining and the detection of hydroxyproline...
et al. A critical role of AREG for bleomycin-induced skin fibrosis. Cell Biosci. 11, 40. https://doi.org/10.1186/S13578-021-00553-0 (2021). Article CAS PubMed PubMed Central Google Scholar Zhang, X. F. et al. Electroacupuncture inhibits IL-17/IL-17R and post-receptor MAPK ...
A novel small compound that antagonizes TGF-β/Smad signaling ameliorates bleomycin-induced skin fibrosisdoi:10.1016/j.jdermsci.2017.02.077Luong, Vu H.Chino, TakenaoTokuriki, AtsushiOyama, NoritakaSasaki, YokoOgura, DaiNiwa, SinichiroFujita, Mikako...
At the time of study termination, we observed significant reduction in dorsal skin thickness. Our results indicate that WFA was able to sufficiently suppress pro-inflammatory phase of fibrosis, TGF-尾/Smad signaling and also significantly repressed fibroblast conversion to myofibroblasts. Additionally, ...
This study aims to investigate the protective efficacy of rituxi- mab on skin fibrosis in bleomycin (BLM) -induced experimental scleroderma model. This study in- cluded 4 groups of (n=7 for each group) Balb/c mice Group I mice were treated with subcutaneous 100 ul/day phosphate-buffered ...
Here, we studied the role of endogenous BMP signaling in lung and skin fibrosis using bleomycin-induced mouse models of fibrosis in wild-type (WT) and noggin (Nog) haploinsufficient (Nog +/LacZ) mice. NOG is a secreted extracellular BMP antagonist that binds different BMPs thereby interfering...
Recent studies have demonstrated the evidence of the crucial role of transforming growth factor-β (TGF-β) in the pathogenesis of tissue fibrosis; however, its precise role has not been fully elucidated. Administration of anti-TGF-β antibody is shown to be effective for inhibiting lung fibrosis...
Y. et al. A critical role of AREG for bleomycin-induced skin fibrosis. Cell Biosci. 11, 40. https://doi.org/1 0.1 186/S13578- 021-00553-0 (2021). 73. Zhang, X. F. et al. Electroacupuncture inhibits IL-17/IL-17R and post-receptor MAPK signaling ...
(5R)-5-hydroxytriptolide; bleomycin; lung fibrosis; cytokines 1 This work was supported by grants from the Knowledge Innovation Program of the Chinese Academy of Sciences (No KSCX2- SW-202) and the Shanghai Science and Technology Committee (No 03DZ19228) 4 Correspondence to Dr Jian-ping ZUO...