We established a bleomycin (BLM)-induced pulmonary fibrosis model in Pink1 knockout ( Pink1 / ) mice and treated BEAS-2B cells with transforming growth factor-beta 1 (TGF-尾1) to simulate the microenvironment of pulmonary fibrosis. A significant elevation in PINK1 expression was observed in ...
Amelioration of bleomycin-induced pulmonary fibrosis in hamsters by combined treatment with taunine and niacin - Wang, Gin, et al. - 1991 () Citation Context ...-1 overexpression to be beneficial in a bleomycininduced pulmonary fibrosis model in mice (60). Similarly, both bilirubin and CO ...
The pulmonary fibrosis model in mice was prepared by atomization inhalation of bleomycin. When the mice were awake, they were put into a transparent plexiglass box with 30 cm × 30 cm × 20 cm connected with the atomizer and atomized 5 g/L (50%) bleomycin diluent was sprayed into the box...
Therefore, Box A could be a novel therapeutic agent for treating pulmonary fibrosis. In this study, we investigated the ability of Box A to alleviate bleomycin-induced pulmonary fibrosis in a rat model. We used this model because the rat that received bleomycin had been shown to develop the ...
We studied the effects of AMD3100, CXCR4 antagonist, on a murine bleomycin-induced pulmonary fibrosis model. Treatment of mice with AMD3100 in bleomy- cin-treated mice resulted in the decrease of SDF-1 in bronchoalveolar lavage (BAL) fluids at an early stage and was followed by the ...
The antifibrotic effects of an interferon inducer, polyinosinic-polycytidylic acid complexed with poly-L-lysine (poly ICLC), was evaluated in a bleomycin-hamster model of pulmonary fibrosis. Hamsters received three consecutive intratracheal doses of bleomycin (2.5, 2.0, and 1.5 U/kg/5 ml) or ...
animal model, we found that ATF-4 and eIF2α were activated immediately following bleomycin treatment, while levels of GRP78 and CHOP expression increased from day 7 through day 14. To further investigate whether an ER stress inhibitor could be used in the treatment of pulmonary fibrosis, 4-...
Therefore, BLM instillation in mice is the most frequent model used to investigate pulmonary fibrosis. Angiotensin 1-7 [Ang-(1-7)] is a heptapeptide with anti-inflammatory and proresolving activity. Here, we studied the effects of preventive and therapeutic oral administration of Ang-(1-7) in...
To further evaluate this hypothesis, our laboratory measured this ratio in a bleomycin (BLM) model of pulmonary fibrosis, which involved different microarchitectural changes than those associated with pulmonary emphysema. METHODS: Syrian hamsters were instilled intratracheally with 1.0 unit BLM in 0.2ml...
Disturbance of serum lipid metabolites and potential biomarkers in the Bleomycin model of pulmonary fibrosis in young mice Article Open access 04 May 2022 References Aleshina, E. Y., Yudanova, T., & Skokova, I. (2001). Production and properties of polyvinyl alcohol spinning solutions contai...