Pulmonary Fibrosis博来霉素磷脂酶A类肺纤维化Pulmonary fibrosis is an interstitial disorder of the lung parenchyma whose mechanism is poorly understood. Potential mechanisms include the infiltration of inflammatory cells to the lungs and the generation of pro-inflammatory mediators. In particular, idiopathic ...
Bleomycin was once used as an antineoplastic agent, but is now thought to cause dose-dependent interstitial pulmonary fibrosis4. Intratracheal administration of bleomycin to the lungs of rodents has been shown to cause alveolar cell damage, an inflammatory response, epithelial-mesenchymal transition (EM...
pulmonary fibrosis bleomycin更多:https://www.bmcx.com/ 翻译结果(简体中文)1: 肺间质纤维化博莱霉素更多:https://www.bmcx.com/ 翻译结果(简体中文)2: 博莱霉素肺纤维化更多:https://www.bmcx.com/ 翻译结果(简体中文)3: 肺纤维化bleomycin更多:https://www.bmcx.com/...
Accumulation of the drug leads to vascular and cell damage, inducing an inflammatory process with influx of macrophages and fibroblasts in lung parenchyma, ultimately leading to lung fibrosis [18–20]. Pulmonary toxicity of bleomycin increases with impaired renal function at the time of administration...
The pulmonary toxicitymay first occur as pneumonitis (inflammation of lung tissue),which normally responds to glucocorticosteroid therapy.Chronic pulmonary toxicity is expressed as pulmonaryfibrosis, which is irreversible and limits utility of the agent. General Description Colorless or yellowish powder. ...
(Reinert, Baldotto, Nunes, & Scheliga, 2013) Recent studies have investigated the potential CAPE, in mitigating theadverse effectsof bleomycin-induced pulmonaryfibrosis. Inpreclinical studies, CAPE has shown promising results in reducing inflammation, oxidative stress, and fibrosis in the lung tissues...
ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial-mesenchymal transition and inflammation. Cell Death Dis. 2020 Nov 13;11(11):978.[5]. Kang Miao, et al. Scutellarein inhibits BLM-mediated pulmonary fibrosis by affecting fibroblast differentiation, proliferation, and ...
Effect of Phoenix dactylifera L. Sap Against Bleomycin-Induced Pulmonary Fibrosis and Oxidative Stress in Rats: Phytochemical and Therapeutic AssessmentLung fibrosis is a lethal interstitial disease characterized by massive proliferation of fibroblast inducing excessive collagen deposition. We aimed to ...
Naftopidil inhibits prostate fibroblast proliferation; however, its effects on lung fibroblasts and fibrosis remain largely unknown. Two normal and one idiopathic pulmonary fibrosis human lung fibroblast lines were cultured with various naftopidil concentrations with or without phenoxybenzamine, an ...
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