The mouse bleomycin-induced fibrosis model was developed to investigate lung fibrosis and widely used over the years. However, a systematic analysis of the accumulated results has not been performed. We undertoo
Alvarez-Erviti, LydiaRuíz-Martínez, CarlosPichel, José G.Sci RepScientific ReportsSergio, Pi?eiro-Hermida,Icíar P,etc.IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model.[J].2017,7(1)....
As with most of the other mouse models described in this article, bleomycin-induced lung fibrosis is strain-dependent with maximal responses seen in C57BL6 and less robust response seen in BALB/c mice. Other strains such as C3H/J show an intermediate response. Thegenetic factorscontrolling thes...
Anti‐Fibrotic Effects of HDAC8 Inhibitor in Bleomycin‐Induced Pulmonary Fibrosis Mouse Model–Whole Transcriptome Analysis Using RNA‐seqBackground Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with high mortality. Current therapies for IPF have only limited efficacy, thus ...
lung fibrosis models Benjamin Strobel, Holger Klein, Germán Leparc, Birgit E. Stierstorfer, Florian Gantner & Sebastian Kreuz* We have previously established a novel mouse model of lung fibrosis based on Adeno-associated virus (AAV)-mediated pulmonary overexpression of TGFβ1. ...
We tested the effect of a DP-specific agonist, (4S)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid (BW245C), on pulmonary fibroblast functions in vitro and in a mouse model of lung fibrosis induced by bleomycin. DP mRNA expression was detected in ...
Yang J, Shi X, Gao R, Fan L, Chen R, Cao Y, et al. Polydatin alleviates bleomycin-induced pulmonary fibrosis and alters the gut microbiota in a mouse model. J Cell Mol Med. 2023;27(23):3717–28. CASPubMedPubMed CentralGoogle Scholar ...
Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury 上传人:hop22·上传时间:2015-12-06
In addition, spermidine enhanced beclin-1-dependent autophagy and autophagy modulators in IPF fibroblasts and BLM-induced mouse lungs, in which inflammation and collagen deposition were significantly decreased. This beneficial effect was related to the antiapoptotic downregulation of the ERS pathway, anti...
Experimental model of bleomycin-induced lung fibrosis Lung fibrosis was induced as described by previous studies with minor modifications[4,16]. Briefly, after the body weight was recorded, the mice were anesthetized via intraperitoneal injection of 30 mg/kg pentobarbital sodium. A midline inci- ...