Then succinate contributes to glycolysis upregulation and FAO downregulation by stabilizing HIF-1伪, which promotes the development of lung fibrosis. In addition, we identify a near-infrared small molecule dye, IR-780, as a targeting agent which stimulates mild inhibition of succinate dehydrogenase ...
Lung fibrosis was established in mice using bleomycin (BLM), and exogenous spermidine was administered daily by intraperitoneal injection (50 mg/kg in phosphate-buffered saline). BLM-induced alveolar epithelial cells showed significant increases in apoptosis and endoplasmic reticulum stress (ERS)-...
Acta Pharmacol Sin 2007 Apr; 28 (4): 518–525 Full-length article (5R)-5-hydroxytriptolide (LLDT-8) protects against bleomycin-induced lung fibrosis in mice1 Yong-xin REN2, Ru ZHOU2, Wei TANG2, Wen-hai WANG2, Yuan-chao LI3, Yi-fu YANG2, Jian-ping ZUO2,4 2Laboratory of ...
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disorder marked by deteriorating dyspnea and declining pulmonary function. Despite its rising prevalence and incidence, therapeutic options remain limited. PTEN-induced kinase 1 (PINK1), known for its role in PINK1/Parkin-dependent mitop...
Histopathological assessment of lung fibrosis models includes routine scoring of resulting fibrosis and inflammation. The goal of this study was to develop methods for automatic quantification of collagen deposits and inflammatory infiltration in the lungs of bleomycin‐treated mice, and to compare the ...
www.nature.com/scientificreports OPEN Time and phenotype‑dependent transcriptome analysis in AAV‑TGFβ1 and Bleomycin‑induced lung fibrosis models Benjamin Strobel, Holger Klein, Germán Leparc, Birgit E. Stierstorfer, Florian Gantner & Sebastian Kreuz* We have ...
www.nature.com/scientificreports OPEN Overexpression of fatty acid synthase attenuates bleomycin induced lung fibrosis by restoring mitochondrial dysfunction in mice Hyesun Shin 1,4, Shinhee Park 1,4, Jisu Hong 1, Ae‑Rin Baek 1, Junehyuk Lee 1, Do‑Jin Kim...
We aimed to investigate whether Date palm sap (DPS) can play a protective effect on bleomycin (BLM)-induced lung fibrosis in rats. MaleWistar rats were given single dose of BLM (4 mg/kg, intra-tracheal), while DPS (45 mg/kg, intraperitoneal) was administered three days later and...
Effects of naftopidil on bleomycin‐induced lung fibrosis in mice were evaluated using histology, micro‐computed tomography, and surfactant protein‐D levels in serum. Naftopidil, dose‐dependently but independently of phenoxybenzamine, inhibited 5‐bromo‐2ʹ‐deoxyuridine incorporation in lung ...
lung fibrosis, through myofibroblastic differentiation of fibroblasts; however, the precise role of ER stress in lung fibrosis is unknown. The current study aimed to investigate the underlying mechanisms of ER stress inhibitors in the treatment of bleomycin-induced lung fibrosis. We demonstrated that ...