Wang J, Jiao H, Stewart TL, Shankowsky HA, Scott PG, Tredget EE. Increased severity of bleomycin-induced skin fibrosis in mice with leukocyte-specific protein 1 deficiency. J Invest Dermatol. 2008; 128 :2767–2776. doi: 10.1038/jid.2008.164. [ Cross Ref ]...
Here, we found that GSDMD was significantly up-regulated and activated in the skin of scleroderma patients and bleomycin-induced mouse model. What’s more, the ablation of GSDMD ameliorates bleomycin-induced skin fibrosis according to HE staining, Masson staining and the detection of hydroxyproline...
Vorstenbosch J, Al-Ajmi H, Winocour S, Trzeciak A, Lessard L, Philip A (2013) CD109 overexpression ameliorates skin fibrosis in a mouse model of bleomycin-induced scleroderma. Arthritis Rheum 65:1378–1383Vorstenbosch J, et al. CD109 overexpression ameliorates skin fibrosis in a mouse model...
[2] Li R, Yin H, Wang J, He D, Yan Q, Lu L. Dihydroartemisinin alleviates skin fibrosis and endothelial dysfunction in bleomycin-induced skin fibrosis models. Clin Rheumatol. 2021;40(10):4269-4277. doi:10.1007/s10067-021-05765-w(IF:2.980) ...
555 Systemic HMGB1 administration ameliorates bleomycin-induced skin fibrosis by promoting accumulation of bone marrow-derived mesenchymal stem cells to the lesion 来自 学术范 喜欢 0 阅读量: 6 作者:Komurasaki, Y,Aikawa, E,Katamaya, I,Tamai, K ...
The mortality from bleomycin-induced lung injury depends on the type and degree of injury and on the presence of risk factors such as advanced age and renal insufficiency.22,23 For pulmonary fibrosis related to bleomycin, mortality estimates have ranged from 2% to 60%.23 Bleomycin is cleared ...
Both the epidermal hyperproliferation and the formation of matriptase-induced skin tumors are completely abolished by coexpression of HAI-1, demonstrating that the proteolytic activity of matriptase is critical to its oncogenic potential. The molecular mechanisms of matriptase-induced epithelial ...
Bleomycin hydrolase, which inactivates bleomycin, is an enzyme that is abundant in liver and kidney but virtually absent in lungs and skin; the latter two organs are the major targets of bleomycin toxicity. It is thought that bleomycin-induced dermal and pulmonary toxicities are related to the ...
Bleomycin hydrolase, which inactivates bleomycin, is an enzyme that is abundant in liver and kidney but virtually absent in lungs and skin; the latter two organs are the major targets of bleomycin toxicity. It is thought that bleomycin-induced dermal and pulmonary toxicities are related to the ...
In approximately 1%, the nonspecific pneumonitis induced by bleomycin progresses to pulmonary fibrosis and death. Although this is age and dose related, the toxicity is unpredictable. Frequent roentgenograms are recommended (see ADVERSE REACTIONS, Pulmonary). A severe idiosyncratic reaction (similar ...