Both fibrosis and pneumonitis are serious concerns for patients who receive bleomycin and may lead to death. Therefore, the management of lung toxicity following cancer therapy with bleomycin is a critical issue. This review explains the cellular and molecular mechanisms of pulmonary injury following ...
All-transretinoic acid ameliorates bleomycin-induced lung fibrosis by downregulating the TGF-β1/Smad3 signaling pathway in rats. J Wuhan Univ Sci Technol. 2013;93:1219-31.Song X, Liu W, Xie S, Wang M, Cao G, Mao C, Lv C (2013) All-transretinoic acid ameliorates bleomycin-induced ...
(5R)-5-hydroxytriptolide; bleomycin; lung fibrosis; cytokines 1 This work was supported by grants from the Knowledge Innovation Program of the Chinese Academy of Sciences (No KSCX2- SW-202) and the Shanghai Science and Technology Committee (No 03DZ19228) 4 Correspondence to Dr Jian-ping ZUO...
The aim of this paper is to study the variation in the expression of p21, p53, p27, and PCNA and to describe the cellular pathology in bleomycin-induced lung fibrosis using animal mouse models. Understanding the cellular and molecular pathology of the diseases hopefully would lead to better an...
Pulmonary fibrosis is characterized by the destruction of normal lung tissue and then replacement by abnormal fibrous tissue, leading to an overall decrease in gas exchange function. The effective treatment for pulmonary fibrosis remains unknown. The ups
Bleomycin treatment in rats results in pulmonary fibrosis that is characterized by a rapid shallow breathing pattern, a decrease in quasi-static lung compliance and a blunting of the Hering-Breuer Inflation Reflex. We examined the impulse activity of pulmonary vagal afferents in anesthetized, mechanical...
The loss of normal alveolar capillary and deregulated angiogenesis occurs simultaneously in idiopathic pulmonary fibrosis (IPF); however the contributions
Oxidative stress has been implicated in the pathogenesis of bleomycin-induced lung fibrosis and many antioxidant agents have been studied for prevention and treatment of the disease in animals and humans. We therefore examined whether Ginkgo biloba (Gb), a flavonoid-rich antioxidant, inhibits bleomycin...
Lung fibrosis was established in mice using bleomycin (BLM), and exogenous spermidine was administered daily by intraperitoneal injection (50 mg/kg in phosphate-buffered saline). BLM-induced alveolar epithelial cells showed significant increases in apoptosis and endoplasmic reticulum stress (ERS)-...
We found that miR-877-3p sequestration inhibited the myofibroblast differentiation of LR-MSC and attenuates bleomycin-induced lung fibrosis by targeting Smad7. Smad7, as an inhibitory smad in the TGF-β1 signaling pathway, was decreased in the myofibroblast differentiation of LR-MSC and up-...