: any of a large class of natural and semisynthetic antibiotics (as the penicillins and cephalosporins) with a lactam ring Dictionary Entries Near beta-lactam beta interferon beta-lactam beta-lactamase See More Nearby Entries Cite this Entry Style “Beta-lactam.” Merriam-Webster.com ...
The Beta-lactamase protein family is vital in countering Beta-lactam antibiotics, a widely used antimicrobial. To enhance our understanding of this family, we adopted a novel approach employing a multiplex network representation of its multiple sequence alignment. Each network layer, derived from the ...
Beta-lactamase inhibitors The beta-lactamase inhibitors encompass several drugs important for the treatment of nosocomial infections. Sulbactam, clavulanic acid, and tazobactam are the most common members of this class employed for the treatment of Acinetobacter infection. Beta-lactamase inhibitors have very...
Negligible influence of metals on -lactamase activity ruled out that Sml-1 is a Zn2+-dependent class B beta-lactamase. Rather, sequence motifs such as SITK, YSN, and HDG forming the active core in a hypothetical structure may be typical for class C beta-lactamases. Based on the results, ...
Molecular basis of antibiotic resistance and β‐lactamase inhibition by mechanism‐based inactivators: perspectives and future directions Antibacterial chemotherapy is particularly striking in the family of penicillins and cephalosporins. Over 40 structurally different β-lactam molecules are... C Therrien,...
Mutations at residue 244 (Ambler numbering system) in the class A TEM beta-lactamase confer resistance to inactivation by beta-lactamase inhibitors and result in diminished turnover of beta-lactam substrates. The Arg244Ser mutant of the OHIO-1 beta-lactamase, an SHV family enzyme, demonstrates va...
Class A according to Ambler’s classification (Ambler et al., 1991;Bush and Jacoby, 2010). This 2be group ofenzymesgathers β-lactamases with activity toward broad-spectrumcephalosporins(ceftazidime,cefotaxime, ceftriaxone) and inhibited by β-lactamase inhibitors (tazobactam,clavulanic acid, sulbactam...
JC Vazquez-Ucha,D Rodriguez,C Lasarte-Monterrubio,... - 《Journal of Medicinal Chemistry》 被引量: 0发表: 2021年 Genetic Context and Biochemical Characterization of the IMP-18 Metallo-β-Lactamase Identified in a Pseudomonas aeruginosa Isolate from the United States The production of metallo-β-...
YbxI belongs to the penicillin-recognizing enzyme family but has an activity intermediate between those of a penicillin-binding protein and a beta-lactamase. 展开 关键词: Bacillus subtilis ßLactamase Activity DOI: 10.1128/AAC.48.2.484-490.2004 ...
www.nature.com/scientificreports OPEN A new class A beta‑lactamase gene blaCAE‑1 coexists with blaAFM‑1 in a novel untypable plasmid in Comamonas aquatica Ying Li 1,2, Chengju Fang 1, Xu Wang 1, Qian Liu 3, Yichuan Qiu 1, Xiaoyi Dai 1...