Class C β-lactamases: an increasing problem worldwide. Rev Med Microbiol. 2004;15:141-152Beceiro A, Bou G. Class C -lactamases: an increasing problem worldwide. Rev Med Microbiol 2004;15:141-52.Class C beta-Lactamases:an increasing problem worldwide. BECEIRO A,BOUG. Reviews in ...
The Atomic Resolution Structure of a Class C β-lactamase and of its Complex with Avibactamantibioticsdrug designenzymesinhibitorsX-ray diffractionbeta-Lactamases (BLs) are important antibiotic-resdoi:10.1002/cmdc.201800213MANGANI, STEFANOPozzi, Cecilia...
beta-Lactamases from all three classes, A, B, and C, catalyze the hydrolysis of specific acyclic depsipeptide (PhCH2CONHCR1R2CO2CHR3CO2H) analogs of acyl-D... R,F,Pratt,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 80发表: 1984年...
1981. ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type. Proc. ... B, Jaurin,T, Grundstrm 被引量: 0发表: 2019年 Evolutionary origin of the class A and class C beta-lactamases. The protein sequences...
class D beta-lactamases, which contain a glutamate residue and a carbamylated lysine in their respective active sites that are thought to serve as general base catalysts for beta-lactam hydrolysis, the mechanism of activation of the serine and water nucleophiles in the class C enzymes is unclear...
Negligible influence of metals on -lactamase activity ruled out that Sml-1 is a Zn2+-dependent class B beta-lactamase. Rather, sequence motifs such as SITK, YSN, and HDG forming the active core in a hypothetical structure may be typical for class C beta-lactamases. Based on the results, ...
1997. AmpC and AmpH, proteins related to the class C beta-lactamases, bind penicillin and contribute to the normal morphology of Escherichia coli. J ... T A,Henderson,K D,... - 《Journal of Bacteriology》 被引量: 105发表: 1997年 AmpC and AmpH, proteins related to the class C ......
Surveys of β-lactamases in different parts of the world show an important increase in class C β-lactamases, thus the study of these enzymes is becoming an important issue. We created an overproduction system for Mox-1, a plasmid class C β-lactamase, by cloning the gene encoding this enzy...
The deduced translated product was a 383-amino acid protein (BUT-1) with 75-78% identity with the chromosomal AmpC beta-lactamases of Citrobacter freundii, Enterobacter aerogenes, Enterobacter cloacae and Escherichia coli. The isoelectric point of 9.0 and the kinetic constants of BUT-1 were ...
Crystal Structures of Substrate and Inhibitor Complexes with AmpC β-Lactamase: Possible Implications for Substrate-Assisted Catalysis Group I β-lactamases are major resistance determinants to β-lactam antibiotics. Despite intense study, the identity of the catalytic base, the direction of hydrolytic ...