In the classes A, the TEM family is one of the most commonly found plasmid-mediated beta-lactamases within Gram-negative bacteria [2]. Through the deprotonation of side-chain OH group, the Ser70 residue of the TEM beta-lactamase in the active site is activated by Glu166 to form Ser70 ...
Outbreak of TEM-24-producing Enterobacter aerogenes in an intensive care unit and dissemination of the extended-spectrum beta-lactamase to other members of... Enterobacter aerogenes in an intensive care unit and dissemination of the extended-spectrum beta-lactamase to other members of the family ...
The enzyme TEM beta-lactamase has been used as a model for understanding the pathway leading to formation of inclusion bodies in Escherichia coli. The equilibrium denaturation of TEM beta-lactamase revealed that an intermediate that has lost enzymatic activity, native protein fluorescence, and UV abso...