Advancing a robust portfolio of best-in-class, clinical-stage products, the company’s lead program is based on xeruborbactam, an investigational beta-lactamase inhibitor discovered by Qpex scientists. For more information, please visit www.qpexbio.com . Forward-Looking Statements This announcement ...
The crystal structure of the TEM1 β-lactamase has been determined at 1.9Å resolution by the molecular-replacement method, using the atomic coordinates of two homologous β-lactamase refined structures which show about 36% strict identity in their amino-acid sequences and 1.96Å r.m...
Enterobacter aerogenes in an intensive care unit and dissemination of the extended-spectrum beta-lactamase to other members of the family Enterobacteriaceae. J... C Neuwirth,E Siebor,J Lopez,... - 《Journal of Clinical Microbiology》 被引量: 422发表: 1996年 Antibiotic resistance: Detection of ...
Raquet X, Lamotte-Brasseur J, Fonz E, Goussard S, Courvalin P, Frere JM. 1994. TEM beta-lactamase mutants hydrolysing third-generation cephalosporins: a kinetic and molecular modelling analysis. J. Mol. Biol. 244:625- 639. http://dx.doi.org/10.1006/jmbi.1994.1756....
Sequence analysis of PER-1 extended-spectrum beta-lactamase from Pseudomonas aeruginosa and comparison with class A beta-lactamases. We have determined the nucleotide sequence (EMBL accession number, Z 21957) of the cloned chromosomal PER-1 extended-spectrum beta-lactamase gene from a Ps... P Nor...
The highly conserved 14-3-3 protein family has risen to a position of importance in cell biology owing to its involvement in vital cellular processes, such... DK Morrison - 《Trends in Cell Biology》 被引量: 929发表: 2009年 TEM-72, a new extended-spectrum beta-lactamase detected in Prote...
Beta-lactamase proteins are broadly categorized into four major classes, namely, A, B, C, and D, based on structural similarity [9]. Classes A, C, and D share the same serine-mediated catalytic mechanism for inactivating beta-lactams, while class B is a family of metalloenzymes that use...