BAP1-IN-1 是一种 BRCA1 相关蛋白 1 (BAP1) 催化活性抑制剂,其作用与癌症相关,可用于研究癌症。 规格价格库存数量 1 mg ¥ 143 现货 5 mg ¥ 297 现货 10 mg ¥ 488 现货 25 mg ¥ 789 现货 50 mg ¥ 1,180 现货 100 mg ¥ 1,760 现货 200 mg ¥ 2,590 现货 1 mL...
These lesions should be considered in the context of a dermal, lobulated atypical spitzoid tumour, particularly where there is a strong family history. In these cases, aBAP1immunostain should be requested and this diagnosis can be confirmed through the loss of nuclear staining. Clinicians should ...
tumor immunity, and cellular metabolism through multiple pathways. In melanoma, BAP1 mutations promote tumor cell glycolysis, leading to increased lactate production. The tumor microenvironment with high lactate levels is often associated with immunosuppression and tumor progression. The inhibitory ...
In contrast to melanoma cells, stable overexpression of BAP1 into immortalized but non-transformed melanocytes did suppress proliferation and reduce survivin. Taken together, these studies demonstrate that BAP1 may have a growth-sustaining role in melanoma cells, but that its impact on ubiquitination ...
The deubiquitinating enzyme BAP1 is an important tumor suppressor that has drawn attention in the clinic since its loss leads to a variety of cancers. BAP1 is activated by ASXL1 to deubiquitinate mono-ubiquitinated H2A at K119 in Polycomb gene repression
BAP1 knockout in ccRCC cells also downregulated the expression of transcriptional repressor protein Snail and decreased the activity of Rho family GTPases, promoting the cells to undergo mesenchymal-epithelial transition. Unexpectedly, quantitative proteomics also showed that BAP1 knockout increased ...
Conversely, knockdown of BAP1 in PCa cells leads to the decrease in PTEN protein level and the activation of the Akt signaling pathway, therefore promoting malignant transformation and cancer metastasis. However, these can be reversed by the re-expression of PTEN. More importantly, we found that...
Germline mutations in the BRCA-1 associated tumor protein 1 (BAP1) increase susceptibility to mesothelioma and other cancers. We describe a patient with a family history of peritoneal mesothelioma, who developed malignant peritoneal mesothelioma at age 45 in the absence of known asbestos exposure. Th...
基于这一发现,研究小组与西北大学细胞与发育生物学教授Milan Mrksich博士领导的团队合作,进行了30 000多个小分子候选物高通量筛选,并确定了一个first-in-class的小分子抑制剂,命名为iBAP,它能够在体外和体内有效抑制BAP1的活性。 iBAP的结构和Ub-AMC(泛素水解酶的荧光底物,在与识别泛素的蛋白酶如BAP1共培养后,AMC...
(100KGP) is a large UK-wide initiative to provide genetic diagnosis to previously undiagnosed patients and families with rare conditions. Over 400 HSP families were recruited to the 100KGP. In order to obtain genetic diagnoses, gene-based burden testing was carried out for rare, predicted ...