To date, only few cases of BAP1-inactivated melanomas have been reported. We present a case of a 35-year-old woman presented with a melanocytic lesion microscopically composed of 3 distinct melanocytic populations, suggesting a stepwise progression model to melanoma from a conventional nevus ...
BAP1-inactivated nevusBAP1-TPDSBRCA-associated protein 1basal cell carcinomacutaneous melanomauveal melanoma, -TPDS. Clinical presentation of BAP1-inactivated nevus, right lateral canthus. ,Scanning magnification of -inactivated nevus shows dome-shaped to polypoid silhouette with increased cellularity ...
BAP1 inactivated melanocytic nevusgenetic diseases/mechanismsglomus juglare tumormelanomanevi‐melanocyticparagangliomaBRCA 1‐associated protein 1( BAP 1) inactivated melanocytic nevi are pink to tan and dome‐shaped in clinical appearance, resembling dermal nevi, but with distinct histologic features of ...
NEVUSBRAF genesCutaneous BAP1‐inactivated melanocytomas (BIM) are melanocytic proliferations defined histopathologically by an epithelioid, predominantly dermal melanocytic proliferation with loss of BAP1, and have been largely characterized in adult patients but less well‐described in pediatric coh...
RNA sequencing was performed on three independent lesions spanning the morphologic spectrum: a benign nevus, an atypical tumor, and a melanoma arising from a pre-existing BAP1-inactivated nevus. The three lesions demonstrated largely distinct gene expression and mutational profiles. Gene expression ...
BAP1‐inactivated melanocytic tumor (BIMT)deep penetrating nevus (DPN)PRAMEin a 60-year-old Chinese man with neoplastic basaloid lobules in which sebaceous cells and apocrine differentiation was observed, but intraepidermal apocrine differentiation was not noted. In addition to SCP, other apocrine ...