These tumors have been described with a myriad of terms including: Wiesner nevus, nevoid melanoma‐like melanocytic proliferation (NEMMP), BAP1 mutant Spitz nevus, BAP1 mutant nevoid melanoma, cutaneous BAPoma, and most recently cutaneous BIMT....
BAP1-inactivated nevusBAP1-TPDSBRCA-associated protein 1basal cell carcinomacutaneous melanomauveal melanoma, -TPDS. Clinical presentation of BAP1-inactivated nevus, right lateral canthus. ,Scanning magnification of -inactivated nevus shows dome-shaped to polypoid silhouette with increased cellularity ...
In addition, there were mixed nests of conventional and BAP1-inactivated melanocytes and squeezed remnants of the original nevus. Of the 26 lesions studied, 24 yielded a BRAF mutation, while in the remaining two cases there was a RAF1 fusion. BAP1 biallelic and singe allele mutations were ...
BAP1 inactivated melanocytic nevusgenetic diseases/mechanismsglomus juglare tumormelanomanevi‐melanocyticparagangliomaBRCA 1‐associated protein 1( BAP 1) inactdoi:10.1111/pde.13553Watchorn Richard E.Calonje EduardoTaibjee Saleem M.Pediatr DermatolPediatric Dermatology...
BAP1 inactivated melanocytic nevusgenetic diseases/mechanismsglomus juglare tumormelanomanevi‐melanocyticparagangliomaBRCA 1‐associated protein 1( BAP 1) inactivated melanocytic nevi are pink to tan and dome‐shaped in clinical appearance, resembling dermal nevi, but with distinct histologic features of ...
To date, only few cases of BAP1-inactivated melanomas have been reported. We present a case of a 35-year-old woman presented with a melanocytic lesion microscopically composed of 3 distinct melanocytic populations, suggesting a stepwise progression model to melanoma from a conventional nevus ...
pediatric melanomaSpitz nevusuveal melanomaCutaneous BAP1‐inactivated melanocytomas (BIM) are melanocytic proliferations defined histopathologically by an epithelioid, predominantly dermal melanocytic proliferation with loss of BAP1, and have been largely characterized in adult patients but less well‐...
BRCA1 associated protein (BAP)1-inactivated melanocytic nevus/tumours (BIMN/Ts) are specific skin tumours that appear during the first two decades of life. These lesions must be recognized by dermatologists and pathologists as an early predictive marker of BAP1 cancer syndrome, as they may ...
RNA sequencing was performed on three independent lesions spanning the morphologic spectrum: a benign nevus, an atypical tumor, and a melanoma arising from a pre-existing BAP1-inactivated nevus. The three lesions demonstrated largely distinct gene expression and mutational profiles. Gene expression ...
BAP1‐inactivated melanocytic tumor (BIMT)deep penetrating nevus (DPN)PRAMEin a 60-year-old Chinese man with neoplastic basaloid lobules in which sebaceous cells and apocrine differentiation was observed, but intraepidermal apocrine differentiation was not noted. In addition to SCP, other apocrine ...