intrahepatic cholangiocarcinomaPBRM1AimsBAP1 and PBRM1 expression loss has been observdoi:10.1111/his.13127Misumi, KentoHayashi, AkimasaShibahara, JunjiArita, JunichiSakamoto, YoshihiroHasegawa, KiyoshiKokudo, NorihiroFukayama, MasashiHistopathologyMisumi K, Hayashi A, Shibahara J, Arita J, Sakamoto Y, ...
Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas. Nat. Genet. 45, 1470–1473 (2013). CAS PubMed PubMed Central Google Scholar Bott, M. et al. The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations ...
Current therapeutic options for intrahepatic cholangiocarcinoma (ICC) are very limited, which is largely attributed to poor understanding of molecular pathogenesis of ICC. Breast cancer type 1 susceptibility protein-associated protein-1 (BAP1) has been reported to be a broad-spectrum tumor suppressor in...
macrophages, and uterine natural killer (uNK) cells. The invasion of the uterine stroma by interstitial extravillous trophoblasts (iEVTs) plays a crucial role in establishing and maintaining maternal-fetal immune tolerance. These iEVTs extend into the inner third of the myometrium...
Intrahepatic cholangiocarcinoma (ICC) has universally poor outcome, mainly due to its late clinical presentation. Identification of specific biomarkers and development of effective treatment are still urgently required. Mutations in PBRM-1 and BAP-1 genes, and the expression of S100P have been related...
Intrahepatic cholangiocarcinoma development in a patient with a novel BAP1 germline mutation and low exposure to asbestos - ScienceDirectG Brandi a bM Deserti bA Palloni aD Turchetti cR Zuntini c dF Pedica eG Frega aS DeLorenzo aF Abbati a...
The current classification of primary adult liver cancer distinguishes two main diagnostic categories: hepatocellular carcinoma and cholangiocarcinoma. These are very heterogeneous tumors characterized by different morphological and clinical features, reflecting the variety of oncological agents and the complex ...
BAP1 is frequently mutated in uveal melanomas, malignant mesothelioma and several carcinomas, including a subtype of renal cell carcinoma, intrahepatic cholangiocarcinoma and squamous cell carcinoma of the esophagus. Furthermore, several germline-associated mutations of tumors have been described (BAP1 ...
Current therapeutic options for intrahepatic cholangiocarcinoma (ICC) are very limited, which is largely attributed to poor understanding of molecular pathogenesis of ICC. Breast cancer type 1 susceptibility protein-associated protein-1 (BAP1) has been reported to be a broad-spectrum tumor suppressor ...
CholangiocarcinomaLncRNABAP1NEAT-1GemcitabineCisplatinCombination therapyGenetic alterations in chromatin modulators such as BRCA-1 associated protein-1 (BAP1) are the most frequent genetic alteration in intrahepatic cholangiocarcinomas (CCA). We evaluated the contribution of BAP1 expression on tumor cell ...