Nuclear BAP1 loss is common in intrahepatic cholangiocarcinoma and a subtype of hepatocellular carcinoma but rare in pancreatic ductal adenocarcinomaBAP1Loss of heterozygosity3p21 regionLiver cancerPancreatic cancerDeletion in the 3p21 region, the chromosomal location of BAP1 , has been reported in a ...
Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas. Nat. Genet. 45, 1470–1473 (2013). CAS PubMed PubMed Central Google Scholar Bott, M. et al. The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations ...
Current therapeutic options for intrahepatic cholangiocarcinoma (ICC) are very limited, which is largely attributed to poor understanding of molecular pathogenesis of ICC. Breast cancer type 1 susceptibility protein-associated protein-1 (BAP1) has been reported to be a broad-spectrum tumor suppressor in...
Loss of BAP1 expression occurs frequently in intrahepatic cholangiocarcinoma Medicine (Baltimore), 95 (2016), Article e2491 View in ScopusGoogle Scholar 16 K. Misumi, A. Hayashi, J. Shibahara, J. Arita, Y. Sakamoto, K. Hasegawa, N. Kokudo, M. Fukayama Intrahepatic cholangiocarcinoma frequently...
TheBAP1gene has emerged as a major tumor suppressor mutated with various frequencies in numerous human malignancies, including uveal melanoma, malignant pleural mesothelioma, clear cell renal cell carcinoma, intrahepatic cholangiocarcinoma, hepatocellular carcinoma, and thymic epithelial tumors.BAP1mutations ar...
b. CT of the abdomen prior to surgery identified a 32 mm lobulated lesion in segment 4B of the liver as indicated by the arrow a primary site in the extrahepatic biliary system or upper gastrointestinal tract the lesion was considered to likely represent a primary intrahepatic cholangiocarcinoma....
intrahepatic cholangiocarcinomaPBRM1AimsBAP1 and PBRM1 expression loss has been observdoi:10.1111/his.13127Misumi, KentoHayashi, AkimasaShibahara, JunjiArita, JunichiSakamoto, YoshihiroHasegawa, KiyoshiKokudo, NorihiroFukayama, MasashiHistopathologyMisumi K, Hayashi A, Shibahara J, Arita J, Sakamoto Y, ...
BAP1 is frequently mutated in uveal melanomas, malignant mesothelioma and several carcinomas, including a subtype of renal cell carcinoma, intrahepatic cholangiocarcinoma and squamous cell carcinoma of the esophagus. Furthermore, several germline-associated mutations of tumors have been described (BAP1 ...
Through exomic sequencing of 32 intrahepatic cholangiocarcinomas, we discovered frequent inactivating mutations in multiple chromatin-remodeling genes (including BAP1, ARID1A and PBRM1), and mutation in one of these genes occurred in almost half of the carcinomas sequenced. We also identified frequent...
Furthermore, somatic BAP1 mutations are important drivers for several cancers most notably UM, MMe, RCC, intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC). Emerging evidence substantiates the fundamental role of BAP1 in suppressing cancer initiation and progression by tuning DNA ...