中文名称:BAP1 抑制剂 1 英文名称:BAP1-IN-1 CAS:353495-21-3 品牌: TargetMol 产地: 美国 保存条件: store at low temperature | Shipping with blue ice. 产品类别: 抑制剂 货号: T73343 Product Introduction Bioactivity Name BAP1-IN-1 Description BAP1-IN-1 is an inhibitor of the catalytic activ...
BAP1 inhibitor(Feinberg School of Medicine) 靶点 BAP1 作用机制 BAP1 inhibitors 在研机构 Feinberg School of Medicine 原研机构 Feinberg School of Medicine 在研适应症 白血病 非在研适应症- 最高研发阶段临床前 首次获批国家/地区- 首次获批日期1800-01-20 100 项与BAP1 相关的临床结果 登录后查看更多信息...
Zauderer MG, Szlosarek P, Le Moulec S, Popat S, Taylor P, Planchard D, et al. Phase 2, multicenter study of the EZH2 inhibitor tazemetostat as monotherapy in adults with relapsed or refractory (R/R) malignant mesothelioma (MM) with BAP1 inactivation. JCO 2018;36:8515–8515. Hassan ...
Importantly, depletion of BAP1 confers cellular resistance to bromodomain and extraterminal (BET) protein inhibitor JQ1 and Aurora A kinase inhibitor Alisertib. Furthermore, IHC results of NB tissue array confirmed the positive correlation between BAP1 and MYCN protein. Altogether, our work not only...
CDKN2A是细胞周期依赖性激酶抑制基因(cyclin-dependent kinase inhibitor)的简称,也称多重肿瘤抑制基因(multiple tumor suppressor l,MTS1),通过可变剪切可产生不同的转录本,至少编码3个不同的蛋白,其中的两个蛋白分别为p16(INK4)与p14(ARF),p16为细胞周期蛋白依赖的激酶抑制剂,p14可与MDM2结合防止p53被泛素化降解,...
Collectively, these results prove that PT33 is a covalent inhibitor of BAP1. On the basis of these findings, we next examined whether the covalently interaction of BAP1 with PT33 may alter BAP1 sub-cellular location, and found that after IR treatment, PT33 had no apparent effect on the ...
Zauderermg, Szlosarek PW, Le Moulec S, et al. EZH2 inhibitor tazemetostat in patients with relapsed or refractory, BAP1-inactivated malignant pleural mesothelioma: a multicentre, open-label, phase 2 study. Lancet Oncol. 2022;...
Cells were lysed with radioimmune precipitation assay buffer supplemented with protease inhibitor mixture and sonicated. After centrifugation at 14,000 × g for 15 min at 4 °C, the supernatant was collected. The protein concentration was measured by BCA assay kit. Equal amount of proteins was se...
CDKN2A是细胞周期依赖性激酶抑制基因(cyclin-dependent kinase inhibitor)的简称,也称多重肿瘤抑制基因(multiple tumor suppressor l,MTS1),通过可变剪切可产生不同的转录本,至少编码3个不同的蛋白,其中的两个蛋白分别为p16(INK4)与p14(ARF),p16为细胞周期蛋白依赖的激酶抑制剂,p14可与MDM2结合防止p53被泛素化降解,...
(a) Ub-AMC hydrolysis assay of BAP1 and BAP1/ASXL1DEUin the presence of an H2A peptide that is conjugated to ubiquitin at K119 in a non-hydrolyzable fashion. This conjugate mimics substrates and therefore functions as an inhibitor for Ub-AMC hydrolysis. BAP1 is inhibited more readily by ...