Bax inhibitor 1 (BI-1) was originally discovered as an inhibitor of Bax-induced apoptosis; this review highlights the fundamental importance of BI-1 in a wider context, including in tissue homeostasis and as a regulator of cellular stress. BI-1 has been shown to interact with a broad range...
Bax inhibitor 1 (BI-1) was originally discovered as an inhibitor of Bax-induced apoptosis; this review highlights the fundamental importance of BI-1 in a wider context, including in tissue homeostasis and as a regulator of cellular stress. BI-1 has been shown to interact with a broad range...
X Linked Inhibitor of Apoptosis (XIAP) is a protein that directly inhibits caspases, promoting cell survival by blocking the assembly of pro-apoptotic protein signaling complexes and mediating the expression of anti-apoptotic molecules. AI generated definition based on:Autophagy: Cancer, Other Pathologie...
knockdown of BI-1 expression resulted in apoptosis in cancer cell lines.10 BI-1 blocks Bax-induced cell death downstream of Bax action at the mitochondria, whereas Bcl-2 directly blocks Bax action by physical interactions,10 suggest- ing that BI-1 is a cell death regulator in apoptosis. Subs...
The potent cell death suppression makes this protein family an interesting target for the development of new drugs and gene therapeutic approaches for diseases caused by apoptotic dysregulation, such as cancer. Keywords: Protein family, Bax-inhibitor, programmed cell death, apoptosis inhibitors, ...
Thus, to investigate the function of BI-1 in ES cell survival and neuronal differentiation, we generated mES cell lines that overexpress BI-1 or a carboxy-terminal BI-1ΔC mutant. Overexpression of BI-1 in mES cells significantly increased cell viability and resistance to apoptosis induced by ...
Both the interference of KIRA6 and the over-expression of BI-1 inhibited the expressions of p-IRE1, p-JNK, Bax and caspase-3, and promoted the expression of anti-apoptotic protein Bcl2.Conclusion Over-expression of BI-1 can inhibit the apoptosis of hippocampal neurons in rats with SAH by...
(NK) cell subclusters with cytotoxic and chemokine signatures increased in the combination therapy, while malignant cells from combination therapy were mainly in the apoptotic state, suggesting that mediating tumor cell apoptosis through NK cells is the main synergistic mechanisms of combination therapy....
However, a few studies have indicated that endoplasmic reticulum (ER) stress, caused by apoptosis of alveolar epithelial cells, is involved in the pathogenesis of pulmonary fibrosis.6–8 In addition, evidence of ER stress has been found in the lungs of patients with familial and sporadic IPF.9...
The IF1–OSCP interaction is confirmed by NMR spectroscopy analysis of the recombinant soluble proteins. Overall, our results suggest that the IF1-OSCP interaction protects cancer cells from PTP-dependent apoptosis under normoxic conditions.Similar content being viewed by others Mitochondrial Lon-induced...