Antisense compounds, compositions and methods are provided for modulating the expression of Cellular Inhibitor of Apoptosis-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Cellular Inhibitor of Apoptosis-1. Methods of using these ...
11、AP (inhibitor of apoptosisinhibitor of apoptosis,细胞凋亡抑 制因子) IAP超家族的成员较多,如c-IAP1, c- IAP2,XIAP, NIAP 和Survivin,新的成员在不断的 被发现。IAP家族成员有一个共同的特征,含有一个 或多个个氨基酸的重复序列(BIR),类似于 zinc指状的结构。c-IAP1、 c-IAP2和 XIAP含有环 指装...
et al. Probing the effect of an inhibitor of an ATPase domain of Hsc70 on clathrin-mediated endocytosis. Mol. Biosyst. 11, 2763–2769 (2015). Article CAS Google Scholar Micheau, O. & Tschopp, J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell ...
Herein, we demonstrate that the most potent caspase inhibitor, X-linked inhibitor of apoptosis protein (XIAP), overexpressed in IBC, drives resistance to ADCC mediated by cetuximab (anti-EGFR) and trastuzumab (anti-HER2). Overexpression of XIAP in parental IBC cell lines enhances resistance to ...
This was likely due to the upregulation of the cyclin-dependent kinase (CDK) inhibitor, p21cip1, and decreased expression of Cyclin A [87]. A similar cell cycle defect was observed in cHL cell lines when JNK was inhibited and this was also associated with an up-regulation of p21cip1[88...
The release of cytochrome c into the cytosol results in caspase-3 activation through formation of the cytochrome c/Apaf-1/caspase-9-containing apoptosome complex [29]. Smac/DIABLO or Omi/HtrA2 promotes caspase activation through neutralizing the inhibitory effects of Inhibitor of Apoptosis Proteins ...
Gli antagonist 61 (GANT61) was identified in a screen to be a direct small-molecule compound inhibitor of Gli proteins (Lauth et al., 2007) and is a promising treatment of fibrosis in lung and kidney (Kramann et al., 2015a, Moshai et al., 2014). To elucidate whether pharmacologic ...
[8], likely as a consequence of the loss of Polycomb repressive complexes[9], and to be involved in senescence mediated by ROS as well as oncogenic signaling. Another important piece in the senescence puzzle is theCDK inhibitor p21(also named WAF1 and encoded by CDKN1A locus) that is ...
induced MM cell apoptosis through Bcl-2 proteins family in MM. Furthermore, we validated that Dutasteride, an SRD5A1 inhibitor, induced myeloma cells apoptosis in human myeloma cells and xenograft mouse models. Thus, SRD5A1 might be a considerable therapeutic target in the development of MM ...
K. Enhanced susceptibility of cyclin kinase inhibitor p21 knockout mice to high fat diet induced atherosclerosis. J. Biomed. Sci. 16, 66 (2009). Article PubMed PubMed Central CAS Google Scholar Diez-Juan, A. & Andres, V. The growth suppressor p27Kip1 protects against diet-induced ...