"Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO." J Biol Chem 278(12):10055-60. :Hu S,Yang X.Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO. Journal of Biological Chemistry . 2003...
Cellular Inhibitor of Apoptosis Protein-1 (cIAP1) Plays a Critical Role in β-Cell Survival under Endoplasmic Reticulum Stress. Qi Y, Xia P (2012) Cellular inhibitor of apoptosis protein-1 (cIAP1) plays a critical role in beta-cell survival under endoplasmic reticulum stress: ... - 《Journa...
1. AIM: To study the expression levels of mRNA and protein of inhibitor of apoptosis protein, survivin, in human brain glioma cell lines BT325 and SHG-44 and its significance. 目的:探讨凋亡蛋白抑制因子 (IAP)SurvivinmRNA及蛋白在人脑胶质瘤细胞系BT32 5和SHG 4 4中的表达水平及意义 。 更多...
11、AP (inhibitor of apoptosisinhibitor of apoptosis,细胞凋亡抑 制因子) IAP超家族的成员较多,如c-IAP1, c- IAP2,XIAP, NIAP 和Survivin,新的成员在不断的 被发现。IAP家族成员有一个共同的特征,含有一个 或多个个氨基酸的重复序列(BIR),类似于 zinc指状的结构。c-IAP1、 c-IAP2和 XIAP含有环 指装...
Induction of selective degradation of target proteins by small molecules (protein knockdown) would be useful for biological research and treatment of various diseases. To achieve protein knockdown, we utilized the ubiquitin ligase activity of cellular inhibitor of apoptosis protein 1 (cIAP1), which is...
The mRNA expression of Survivin, X-linked inhibitor of apoptosis protein (XIAP), and Bcl-2-like protein 1 (Bclx) was modestly increased (<2-fold), while expression of BCL2-related protein A1 (BCL2A1) and cellular inhibitors of apoptosis protein 1 and 2 (CIAP1, CIAP2) was significantly...
K. Enhanced susceptibility of cyclin kinase inhibitor p21 knockout mice to high fat diet induced atherosclerosis. J. Biomed. Sci. 16, 66 (2009). Article PubMed PubMed Central CAS Google Scholar Diez-Juan, A. & Andres, V. The growth suppressor p27Kip1 protects against diet-induced ...
The focus of immunotherapy in EOC clinical trials is similar to those of many other cancer subtypes, and programmed cell death 1 (PD-1) is its main inhibitor [61]. The standard of care for all female patients with epithelial ovarian cancer is the genetic identification of altered genes that...
Knockdown of HO-1 expression in cell lines was associated with significantly decreased cellular proliferation (P<0.05) and a higher rate of apoptosis (P<0.001) 48 h after treatment. Treatment of the cell lines with the ROS inhibitor N-acetylcysteine abrogated this effect. Knockdown of HO-1 was...
To validate the inhibitor studies, we tested an E1A-positive RESULTS Sensitivity of E1A-positive human and mouse cells to apoptosis induced by DNA damaging chemotherapeutic agents E1A expression sensitizes mammalian cells to DNA damaging agents that induce apoptosis through the intrinsic pathway.33 We...