The inhibitor of apoptosis protein cIAP1 (cellular inhibitor of apoptosis protein-1) is a potent regulator of the tumor necrosis factor (TNF) receptor family and NF-?B signaling pathways in the cytoplasm. However, in some primary cells and tumor cell lines, cIAP1 is expressed in the nucleus...
1. AIM: To study the expression levels of mRNA and protein of inhibitor of apoptosis protein, survivin, in human brain glioma cell lines BT325 and SHG-44 and its significance. 目的:探讨凋亡蛋白抑制因子 (IAP)SurvivinmRNA及蛋白在人脑胶质瘤细胞系BT32 5和SHG 4 4中的表达水平及意义 。 更多...
(2012). Cellular inhibitor of apoptosis protein-1 (cIAP1) plays a critical role in beta-cell survival under endoplasmic reticulum stress: promoting ... Y Qi,P Xia - 《Journal of Biological Chemistry》 被引量: 75发表: 2012年 Cellular inhibitor of apoptosis protein-1 (cIAP1) plays a critica...
Induction of selective degradation of target proteins by small molecules (protein knockdown) would be useful for biological research and treatment of various diseases. To achieve protein knockdown, we utilized the ubiquitin ligase activity of cellular inhibitor of apoptosis protein 1 (cIAP1), which is...
11、AP (inhibitor of apoptosisinhibitor of apoptosis,细胞凋亡抑 制因子) IAP超家族的成员较多,如c-IAP1, c- IAP2,XIAP, NIAP 和Survivin,新的成员在不断的 被发现。IAP家族成员有一个共同的特征,含有一个 或多个个氨基酸的重复序列(BIR),类似于 zinc指状的结构。c-IAP1、 c-IAP2和 XIAP含有环 指装...
cellular inhibitor of apoptosis protein TRAF TNF receptor-associated factor IL-1 interleukin 1 EMSA electrophoretic mobility shift assay EBV Epstein-Barr virus LMP1 latent membrane protein 1 AP-1 activator protein 1 NFAT nuclear factor of activated T cell LUC luciferase TNFR1 p55 TNF receptor NIK NF...
The mRNA expression of Survivin, X-linked inhibitor of apoptosis protein (XIAP), and Bcl-2-like protein 1 (Bclx) was modestly increased (<2-fold), while expression of BCL2-related protein A1 (BCL2A1) and cellular inhibitors of apoptosis protein 1 and 2 (CIAP1, CIAP2) was significantly...
Key signaling pathways from activated K-Ras that lead to cellular transformation by promoting glycolysis, inhibiting apoptosis through IAPs and ROS detoxification. IAPs, inhibitor of apoptotic proteins (XIAP, cIAP-1/2); IRES, internal ribosome entry site; PKC, protein kinase-C; ROS, reactive ...
9, 10, 11, 12 X-linked inhibitor of apoptosis protein (XIAP), a member of the inhibitor of apoptosis protein (IAP) family, is considered the most potent caspase-binding protein and inhibitor of both the extrinsic and intrinsic death pathways.13 XIAP overexpression in tumor cells is a well-...
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