6) Inhibitor of apoptosis protein 凋亡蛋白抑制因子 1. AIM: To study the expression levels of mRNA and protein of inhibitor of apoptosis protein, survivin, in human brain glioma cell lines BT325 and SHG-44 and its significance. 目的:探讨凋亡蛋白抑制因子 (IAP)SurvivinmRNA及蛋白在人脑胶质瘤...
11、AP (inhibitor of apoptosisinhibitor of apoptosis,细胞凋亡抑 制因子) IAP超家族的成员较多,如c-IAP1, c- IAP2,XIAP, NIAP 和Survivin,新的成员在不断的 被发现。IAP家族成员有一个共同的特征,含有一个 或多个个氨基酸的重复序列(BIR),类似于 zinc指状的结构。c-IAP1、 c-IAP2和 XIAP含有环 指装...
细胞凋亡（Cellularapoptosis）一.细胞凋亡的研究历史 •凋亡概念的形成和形态学的研究(1972Kerr）•DNA的降解和内源性核酸内切酶的参与。(1987）•蛋白质水解酶活化的研究(1995)•细胞膜的变化(1997)•线粒体的变化和分子生物学的研究(1996-)•细胞凋亡--诺贝尔奖(2002)SydneyBrenner,JohnE.Sulston,Robert...
The mRNA expression of Survivin, X-linked inhibitor of apoptosis protein (XIAP), and Bcl-2-like protein 1 (Bclx) was modestly increased (<2-fold), while expression of BCL2-related protein A1 (BCL2A1) and cellular inhibitors of apoptosis protein 1 and 2 (CIAP1, CIAP2) was significantly...
Quaternary screen: RGC-5 cells were treated with mTNF (0.5 ng/ml), TAK1 inhibitor (5Z)-7-Oxozeanol (0.5 μM) and individual compounds (10 μM) for 8 h and cell viability was measured. b, IC50s of ICCB-19 and Apt-1 protecting Velcade-induced apoptosis (50 nM) in Jurkat cells ...
Induction of selective degradation of target proteins by small molecules (protein knockdown) would be useful for biological research and treatment of various diseases. To achieve protein knockdown, we utilized the ubiquitin ligase activity of cellular inhibitor of apoptosis protein 1 (cIAP1), which is...
To inhibit tumor angiogenesis, vasohibin has been identified as an intrinsic and specific angiogenesis inhibitor. The therapeutic potential of the rAd-vasohibin, which encodes vasohibin, has been explored. When administered via tail vein injection, rAd-vasohibin prevented tumor cell growth in a subcutane...
[198,199,200,201,202,203]. BCL-2 is a classic inhibitor of apoptosis. An increased ratio of BCL-2 to BCL-2-associated X protein (BAX) results in cells that are less sensitive to the pathological stimuli and prevents cells from responding to apoptotic signals [204,205]. Transplantation ...
Knockdown of HO-1 expression in cell lines was associated with significantly decreased cellular proliferation (P<0.05) and a higher rate of apoptosis (P<0.001) 48 h after treatment. Treatment of the cell lines with the ROS inhibitor N-acetylcysteine abrogated this effect. Knockdown of HO-1 was...
Herein, we demonstrate that the most potent caspase inhibitor, X-linked inhibitor of apoptosis protein (XIAP), overexpressed in IBC, drives resistance to ADCC mediated by cetuximab (anti-EGFR) and trastuzumab (anti-HER2). Overexpression of XIAP in parental IBC cell lines enhances resistance to ...