Benchokroun Y, Couprie J and Larsen AK (1995) Aurintricarboxylic acid, a putative inhibitor of apoptosis, is a potent inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells. Biochem Pharmacol 49:305-313.Benchokroun Y, Couprie J, Larsen AK. Aurintricarboxilic ...
17. Here we review these data, and provide new data showing that HR corepressor activity is essential for its in vivo function, and identify an additional putative Wnt inhibitor regulated by HR. 我们回顾了这些资料,并提供新的资料显示HR辅阻遏物的活性是其体内作用的要素,并鉴别另外假定被HR调控的Wnt...
Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia. Nat Commun. 2018;9:5341. Varadarajan S, Poornima P, Milani M, Gowda K, Amin S, Wang HG, et al. Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in ...
In male sterility of rice, abnormal programmed cell death during the degradation of tapetal cells is caused by disrupted apoptosis inhibitor5 (API5), a nuclear protein that interacts with two DEAD-box ATP-dependent RNA helicases, API5-INTERACTING PROTEIN1 (AIP1) and AIP2, which regulate the...
Angiostatin binds ATP synthase on the surface of human endothelial cells Angiostatin, a proteolytic fragment of plasminogen, is a potent antagonist of angiogenesis and an inhibitor of endothelial cell migration and proliferation... AMMY L. MOSER,M. SHARON STACK,I Asplin - 《Proceedings of the Natio...
AZD6244 (ARRY-142886) is an orally active and selective inhibitor that specifically targets MEK. We investigated the effect of AZD6244 on NSCLC cell lines to further understand the detailed molecular mechanism contributing to the sensitivity to this drug. Interestingly, two NSCLC cell lines, which ...
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells Nat. Med., 2 (1996), pp. 561-566 View in ScopusGoogle Scholar 5 B.J. Druker, M. Talpaz, D.J. Resta, B. Peng, E. Buchdunger, J.M. Ford, N.B. Lydon, H. Kantarjian, R....
This was supported by the observation that treatment with 5-aza-2'-deoxycytidine, an inhibitor of DNA methylation reduced the degree of methylation and increase the level of MT3 expression, in esophageal SCC cell lines [25]. Significant downregulation of MT3 has been most frequently reported in...
97248_at Diazepam binding inhibitor, acyl-CoA binding proteina −1.0 −1.3 −1.4 1.50E-03 −1.2 −1.9 8.80E-05 1.6 160544_at FABP5, epidermal −2.8 −1.6 −2.8 7.10E-04 −1.9 −2.6 1.00E-01 2.9 101082_at Malic enzymea −1.2 −1.5 −3.0 3.20E-04 −1.8 −...
Conventional differentiation protocols for the generation of inner ear hair cells from stem cells in vitro are multi-step and require the well-timed addition of several exogenous bioactive molecules, such as BMP4, transforming growth factor β inhibitor, FGF2, and Wnt13,14,15. We posited that ...