BAP1-IN-1名称 英文名BAP1-IN-1 BAP1-IN-1生物活性 描述BAP1-IN-1(化合物8)是BRCA1相关蛋白1(BAP1)催化活性抑制剂,IC50为0.1-1μM[1]。 相关类别 研究领域>>癌症 信号通路>>其他>>其他 靶点 IC50: 0.1-1 μM (BAP1)[1] 体外研究BAP1-IN-1(化合物8)(1μM;30分钟)不仅在体外而且在细胞环...
BAP1-IN-1 _ MedChemExpress(MCE) 英文名称: 总访问: 35 国产/进口: 进口 半年访问: 6 产地/品牌: MedChemExpress(MCE) 产品类别: 生化试剂 规格: 5 mg 最后更新: 2024-11-4 货号: HY-W327122 CAS 号: 353495-21-3 参考报价: 370 立即询价 电话咨询 ...
BAP1-IN-1 (Compound 8) 是一种 BRCA1 相关蛋白 1 (BAP1) 催化活性抑制剂,其 IC50 为 0.1-1 μM。 详细介绍 产品活性:BAP1-IN-1 (Compound 8) 是一种 BRCA1 相关蛋白 1 (BAP1) 催化活性抑制剂,其 IC50 为 0.1-1 μM。 品牌介绍: MCE (MedChemExpress) 拥有数百种*仅有化合物,我们致力...
具体来说,突变的ASXL1蛋白形成一个短肽,与BAP1复合物结合,增强和稳定BAP1复合物,激活基因表达,最终促进白血病的发展。 基于这一发现,研究小组与西北大学细胞与发育生物学教授Milan Mrksich博士领导的团队合作,进行了30 000多个小分子候选物高通量筛选,并确定了一个first-in-class的小分子抑制剂,命名为iBAP,它能够...
ABAP1 forms large chromatin-associated protein complexes with a “core complex” containing ASXLs and HCF-1/OGT. The HCF-1 binding motif (HBM) and phosphorylated threonine T493 are found in the unstructured loop of BAP1 (NORS non-organized regions). BAP1 interacts with ASXLs through its DE...
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The tumor suppressor gene BAP1 encodes a widely expressed deubiquitinase for histone H2A. Both hereditary and acquired mutations are associated with multiple cancer types, including cutaneous melanoma (CM), uveal melanoma (UM), and clear cell renal cell
Hypoxia plays an important role in the chemotherapy resistance of nasopharyngeal carcinoma (NPC). Ferroptosis is a newly discovered form of programmed cell death and ferroptosis inducers showed promising therapeutic effects in some cancers. However, the
Mutations of ASXL1, encoding a component of the BAP1 histone H2A deubiquitinase complex, occur in human myeloid neoplasms and are uniformly associated with poor prognosis. However, the precise molecular mechanisms through which ASXL1 mutations alter BAP1
Kaynak Paket: ikarus (0.0.3+bzr.2010.01.26+bap.1-1) [universe] ikarus için bağlantılar Ubuntu Kaynakları: Hata Raporları Ubuntu Değişim Günlüğü Telif Hakkı Dosyası Debian Kaynak Deposu (Git) Geliştirici: Ubuntu MOTU Developers (Posta Arşivi) Please ...