Genetic depletion of BAP1 in melanoma cells reduced proliferation and colony-forming capability, induced apoptosis, and inhibited melanoma tumor growth in vivo. On the molecular level, suppression of BAP1 led to a concomitant drop in the protein levels of survivin, a member of anti-apoptotic ...
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具体来说,突变的ASXL1蛋白形成一个短肽,与BAP1复合物结合,增强和稳定BAP1复合物,激活基因表达,最终促进白血病的发展。 基于这一发现,研究小组与西北大学细胞与发育生物学教授Milan Mrksich博士领导的团队合作,进行了30 000多个小分子候选物高通量筛选,并确定了一个first-in-class的小分子抑制剂,命名为iBAP,它能够...
BRCA1-associated protein 1 (BAP1) acts as a tumor suppressor and can affect the cell cycle, tumor immunity, and cellular metabolism through multiple pathways. In melanoma, BAP1 mutations promote tumor cell glycolysis, leading to increased lactate production. The tumor microenvironment with high lact...
Thomas Wiesner and colleagues report that germline mutations in BAP1 predispose to melanocytic tumors ranging histopathologically from epithelioid nevi to atypical melanocytic proliferations. Some BAP1 mutation carriers also developed uveal or cutaneous
BAP1 knockout in ccRCC cells also downregulated the expression of transcriptional repressor protein Snail and decreased the activity of Rho family GTPases, promoting the cells to undergo mesenchymal-epithelial transition. Unexpectedly, quantitative proteomics also showed that BAP1 knockout increased ...
Hypoxia plays an important role in the chemotherapy resistance of nasopharyngeal carcinoma (NPC). Ferroptosis is a newly discovered form of programmed cell death and ferroptosis inducers showed promising therapeutic effects in some cancers. However, the
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In total, seven families carrying three different truncating variants inUBAP1were identified in the 100KGP data (Table1, ClinVar SUB7456898). Families 1 and 2 were consistent with de novo occurrence of HSP (Fig.1a), while the pedigrees of families 3–7 suggested an AD pattern of inheritance...
Germline mutations in the BRCA-1 associated tumor protein 1 (BAP1) increase susceptibility to mesothelioma and other cancers. We describe a patient with a family history of peritoneal mesothelioma, who developed malignant peritoneal mesothelioma at age 4