中文名1,5-二羟基异喹啉;1,5-异喹啉二醇;PARP-1抑制剂;英文名：1,5-Isoquinolinediol;PARP-1 inhibitor;5-hydroxy-1(2H)-isoquinolinone;NSC 65585 CAS号：5154-02-9 结构式：c1cc2c(ccnc2O)c(c1)O 分子式：C9H7NO2 分子量：161 闪点：256.8±24.6 °C 熔点：270-275 °C 沸点：501.1±30....
中文名1,5-二羟基异喹啉;1,5-异喹啉二醇;PARP-1抑制剂; 英文名:1,5-Isoquinolinediol;PARP-1 inhibitor;5-hydroxy-1(2H)-isoquinolinone;NSC 65585 CAS号:5154-02-9 结构式:c1cc2c(ccnc2O)c(c1)O 分子式:C9H7NO2 分子量:161 闪点:256.8±24.6 °C 熔点:270-275 °C 沸点:501.1±30.0 °C at...
2.S.D. Fontaine, G.W. Ashley, P.J. Houghton, R.T. Kurmasheva, M. Diolaiti, A. Ashworth, C.J. Peer, R. Nguyen, W.D. Figg Sr., D.R. Beckford-Vera, D.V. Santi, A very long-acting PARP inhibitor suppresses cancer cell growth in DNA repair-deficie...
1,Felipe Salech1,2,3 , Daniela P. Ponce1, Andrea C,Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, asan Adjunctive Therapy for the Treatment of Alzheimer’s Disease。Frontiers in Aging Neuroscience 。2020 August. 2,...
产品名：PARP-1抑制剂;PJ34盐酸盐 英文名：PJ34 hydrochloride; PARP-1 inhibitor;PJ34 HCl;PARP Inhibitor VIII,PJ34;CAS号：344458-15-7 结构式：O=C(NC(C=C1C2=C3C=CC=C2)=CC=C1NC3=O)CN(C)C.Cl 分子式：C17H18ClN3O2 分子量：331.8 闪点：279.9°C 沸点：539.1°C at 760 mmHg 溶...
1.Li J，Zhou N，Cai P，et al.In silico screening identifies a novel potential PARP1 inhibitor targeting synthetic lethality in cancer treatment[J].International journal of molecular sciences，2016，17(2)：258.2.http://dock.compbio.ucsf.edu/ 3.http://www.gromacs.org/ 4.http：//rashmikumari...
[2]PARP1 inhibitor HS-10502, from https://www.cancer.gov/publications/dictionaries/cancer-drug/def/parp1-inhibitor-hs-10502 [3]ClinicalTrials官网. From https://clinicaltrials.gov/study/NCT05740956?term=HS-10502&rank=1 （转自：医药观澜）
Luo Q, Li Y, Deng J and Zhang Z: PARP-1 inhibitor sensitizes arsenic trioxide in hepatocellular carcinoma cells via abrogation of G2/M checkpoint and suppression of DNA damage repair. Chem Biol Interact 226: 12-22, 2015.Luo, Q., Li, Y., Deng, J. and Zhang, Z. (2015): PARP-1 ...
[1]CT014.PETRA: first-in-human Phase 1/2a trial of the first-in-class next-generation poly(ADP-ribose) polymerase-1 selective inhibitor (PARP1i) saruparib (AZD5305) in patients (pts) with advanced solid tumors with BRCA1/2, PALB2 or RAD51C/D mutations.2024 AACR. ...
在体内,AG14361按无毒剂量处理,提高Irinotecan,x射线照射,Temozolomide诱导的LoVo移植瘤生长延迟,提高2到3倍。药效学实验检测,AG14361按10mg/kg剂量腹腔注射处理SW620移植瘤至少4小时,75%以上PARP-1活性受抑制。储存条件:-20℃,有效期12个月。相关搜索:PARP1抑制剂(AG14361),PARP1 Inhibitor,328543-09-5...