中文名1,5-二羟基异喹啉;1,5-异喹啉二醇;PARP-1抑制剂; 英文名:1,5-Isoquinolinediol;PARP-1 inhibitor;5-hydroxy-1(2H)-isoquinolinone;NSC 65585 CAS号:5154-02-9 结构式:c1cc2c(ccnc2O)c(c1)O 分子式:C9H7NO2 分子量:161 闪点:256.8±24.6 °C 熔点:270-275 °C 沸点:501.1±30.0 °C at...
它结合并抑制 PARP tankyrase1 (IC50 = 1 μM)。 PJ-34 在以较高浓度使用时也会抑制基质金属蛋白酶2 (IC50 = 56 μM)。 图1.PJ34 hydrochloride化学结构 PJ34 hydrochloride基础信息 产品名:PARP-1抑制剂;PJ34盐酸盐 英文名:PJ34 hydrochloride; PARP-1 inhibitor;PJ34 HCl;PARP Inhibitor VIII,PJ34; ...
[1] 中国国家药监局药品审评中心官网. Retrieved Aug 23, 2024, from https://www.cde.org.cn/main/xxgk/listpage/da6efd086c099b7fc949121166f0130c [2]PARP1 inhibitor HS-10502, from https://www.cancer.gov/publications/dictionaries/cancer-drug/def/parp1-inhibitor-hs-10502 [3]ClinicalTrials官网....
中文名1,5-二羟基异喹啉;1,5-异喹啉二醇;PARP-1抑制剂;英文名：1,5-Isoquinolinediol;PARP-1 inhibitor;5-hydroxy-1(2H)-isoquinolinone;NSC 65585 CAS号：5154-02-9 结构式：c1cc2c(ccnc2O)c(c1)O 分子式：C9H7NO2 分子量：161 闪点：256.8±24.6 °C 熔点：270-275 °C 沸点：501.1±30....
产品名：PARP-1抑制剂;PJ34盐酸盐 英文名：PJ34 hydrochloride; PARP-1 inhibitor;PJ34 HCl;PARP Inhibitor VIII,PJ34;CAS号：344458-15-7 结构式：O=C(NC(C=C1C2=C3C=CC=C2)=CC=C1NC3=O)CN(C)C.Cl 分子式：C17H18ClN3O2 分子量：331.8 闪点：279.9°C 沸点：539.1°C at 760 mmHg 溶...
2.S.D. Fontaine, G.W. Ashley, P.J. Houghton, R.T. Kurmasheva, M. Diolaiti, A. Ashworth, C.J. Peer, R. Nguyen, W.D. Figg Sr., D.R. Beckford-Vera, D.V. Santi, A very long-acting PARP inhibitor suppresses cancer cell growth in DNA repair-deficie...
Polymerase 1 (PARP-1) Inhibitor, asan Adjunctive Therapy for the Treatment of Alzheimer’s Disease。Frontiers in Aging Neuroscience 。2020 August. 2,Ilias P. Nikas, Stavroula A. Paschou,Han Suk Ryu ,The Role of Nicotinamide in Cancer Chem...
PARP-1 inhibitor AG14361 may be a promising agent to attenuate acute allograft rejection as it can maintain the number and function of Treg cells in allografts.doi:10.1016/j.prp.2020.153021Wei GuRuru GeFangming ZhuDan LiJianxin QiuPathology - Research and Practice...
1.Li J，Zhou N，Cai P，et al.In silico screening identifies a novel potential PARP1 inhibitor targeting synthetic lethality in cancer treatment[J].International journal of molecular sciences，2016，17(2)：258.2.http://dock.compbio.ucsf.edu/ 3.http://www.gromacs.org/ 4.http：//rashmikumari...
DPQ is a potent PARP-1 inhibitor. DPQ can reduce the N-methyl-d-aspartate (NMDA)-induced PARP activation, restoring ATP to near control levels and significantly attenuating neuronal injury in the severe NMDA exposure model. DPQ can be used for researching neuroprotection. ...