TIMP~1 阻止胶原降解等ꎬ促进 ECM 合成和细胞 增殖ꎬ收缩肝窦ꎮ PARP~1 主要调控机制见图 1ꎮ 图 1 肝细胞 DNA 损伤使 PARP~1 过度激活促进 HF 的 机制 Fig.1 Mechanism by which hepatocyte DNA injury pro~ motes HF by overactivating PARP~1 2.1 调节肝细胞 NAD+ 和能量代谢ꎬ线粒体稳态...
Based on the structure and mechanism of PARP-1, the major structure types of PARP-1 inhibitors and optimization strategies were reviewed, along with an outlook on their future applications and urgent problems to be solved. [Key words] PARP-1; inhibitor; cancer DNA - Chambon 在细胞的生长过程...
cancer cell lines and found that in HRD cell lines, PARPi therapy reduced non-homologous end joining (NHEJ)-mediated repair, specifically due to decreased theta-mediated end-joining. The combination of PARPi with ATM serine/threonine kinase inhibitor (ATMi) suppressed both NHEJ and HR pathways ...
Our study indicates that the abrogation of G2/M checkpoint and the suppression of DNA damage repair contribute to ATO-sensitization by PARP-1 inhibitor in HepG2 cells, which provides a novel insight into the chemo-sensitization mechanism of PARP-1 inhibitor....
1.To construct the pharmacophore model of the poly(ADP-ribose) polymerase-1 inhibitor and to investigate the possible inhibitory mechanisms,ten pharmacophore models ofPARP-1 inhibitorwere established from the training set of thirty-eightPARP-1 inhibitors with conformer analysis and pharmacophore mapping ...
Iniparib (BSI-201) is an antineoplastic originally thoμght to be a poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor. Recent studies indicate Iniparib is not a PARP-1 inhibitor, and its mechanism of action is currently unknown. 查看阿拉丁官网此产品相关对应页面:https://www.aladdin-e.com/...
Cells were trypsinized, washed with PBS, and resuspended in 25 mL PBS. The cells were then crosslinked in 1 % formaldehyde (Pierce Biotechnology, Rockford, IL, USA), quenched with 0.125 M glycine, and washed twice in PBS containing protease inhibitor (PI; Roche). The fixed cells were lysed...
Role of the PARP1 inhibitor Ico in reversing acquired and primary resistance to TKI. (A) H1299 cells were treated with 0, 2.5, 5, or 10 µM Ico; 2 or 4 µM AZD2281; or a combination of both for 48 h. Cell viability was determined by the CCK-8 assay. The columns represent ...
A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells 2024, Cell Reports Citation Excerpt : An increasing number of proteins, including XRCC1,18,30 TRIP12,31 ALC1,32 RNF114,33 VCP/p97,34 Spartan,35 and HPF1,9 have been proposed to ...
目的探讨微小RNA-222(miR-222)调控多聚二磷酸腺苷核糖聚合酶-1(PARP-1)在高糖诱导人肾脏系膜细胞(HMC)组织型纤溶酶原激活物/纤溶酶原激活物抑制物-1(tPA/PAI-1)紊乱中的作用。方法体外培养HMC,实时定量PCR分别检测正常糖(5 m...