BAP1‐inactivated naevus/melanocytomaBIMTSpitzAlthough discussed using variable terminology, cutaneous BRCA1‐associated protein ( BAP1 )‐inactivated melanocytic tumor (BIMT) has been considered a discrete diagnostic entity since 2011. Here, we review the initial genomic studies that identified these ...
BAP1‐inactivated melanocytomaBAP1 proteinBAPomaBRAFdermal nevuspediatric melanomaSpitz nevusuveal melanomaCutaneous BAP1‐inactivated melanocytomas (BIM) are melanocytic proliferations defined histopathologically by an epithelioid, predominantly dermal melanocytic proliferation with loss of BAP1, and ha...
A presumed pedunculated seborrhoeic keratosis was shave excised by his general practitioner; however, histology revealed a BRCA1-associated protein (BAP1)-inactivated melanocytoma (BIM) with melanoma transformation. Histologically, BIMs are identified by the presence of a dermally located expansile ...
We present a case of a 35-year-old woman presented with a melanocytic lesion microscopically composed of 3 distinct melanocytic populations, suggesting a stepwise progression model to melanoma from a conventional nevus through a melanocytoma stage. This progression was also supported from a molecular ...
The primary melanoma diagnosis was changed to a low-risk BAP1 melanocytoma, based on histological and immunohistochemical findings. Two other low-risk melanocytomas were also excised. The patient was referred to the sarcoma multidisciplinary team, for wide local excision of the MPNST, staging ...