B7-H3在前列腺癌中异常表达,B7-H3可在前列腺癌细胞系PC-3的增殖、侵袭过程中起到作用[16],此外,B7-H3还可通过调节Treg细胞来抑制免疫反应,从而介导肿瘤逃逸免疫反应。较高的B7-H3表达与放疗后生化复发风险增加有关[17]。 此外,B7-H3在肾细胞癌肿瘤组织中和血管周围的肿瘤中高表达,在肾细胞癌中miR-187过表达...
因此,B7-H3的过度表达与肿瘤患者的不良预后以及体外模型中肿瘤的侵袭和转移潜力有关,这也就拓展了和证实了B7-H3在肿瘤治疗中的作用[1,7-10]。 从分子机制上说,尽管B7-H3蛋白的胞内结构域很短,尚未发现已知的信号基序;但是B7-H3蛋白间接激活NF-kΒ、PI3K/Akt和...
前列腺癌转染B7-H3基因Objective To analyze transfection B7-H3 gene of prostate cancer cells to absorb 18f -18f-FDG and the influence of FLT.Methods RM1 detection source sex of the rat prostate cancer cells and RM1-B7-H3 cells after different periods of absorbance (A) value, different ...
货号: B7-H3 Stable Cell Line 用途范围: 生物 是否进口: 否 CHO/Human B7-H3 (4Ig) Stable Cell Line Development Service 描述(Description) The CHO/Human B7-H3 (4Ig) Stable Cell Line was engineered to express the receptor full length human B7-H3 (4Ig) (Gene ID: 80381), used to mi...
近日,天境生物宣布依布妥组单抗与Keytruda(帕博利珠单抗)联合治疗实体瘤的II期临床试验申请获NMPA受理,标志着国内首款B7-H3(也称CD276)药物将开启临床研究。 B7家族成员是免疫治疗的热门靶点,被大家广泛知晓的PD-L1其实就是B7家族成员,也被称作B7-H1或CD274。围绕PD-L1(B7-H1)/PD-1开发的肿瘤免疫治疗药物无论在...
基因别名:4Ig-B7-H3; B7-H3; B7H3; B7RP-2; CD276; PSEC0249; UNQ309/PRO352 UniProt ID:(Human) Q5ZPR3 Entrez Gene ID:(Human) 80381 功能 receptor bindingprotein bindingimmunoglobulin receptor superfamily 参与通路 immune responsecell proliferationpositive regulation of bone mineralizationpositive regul...
基因别名:4Ig-B7-H3; B7-H3; B7H3; B7RP-2; CD276; PSEC0249; UNQ309/PRO352 UniProt ID:(Human) Q5ZPR3 Entrez Gene ID:(Human) 80381 功能 receptor bindingprotein bindingimmunoglobulin receptor superfamily 参与通路 immune responsecell proliferationpositive regulation of bone m...
关键词:B7-H3;髓系来源抑制性细胞;前列腺癌;凋亡。 作者:**峰 指导教师:**全 B7-H3调节髓源性抑制细胞凋亡促进小鼠前列腺癌进展的实验研究英文摘要 III B7-H3RegulatingMyeloid-derivedSuppressorCells ApoptosisinMouseProstateCancerProgression Abstract Objective:WeregulatedmurineprostatecancerRM-1cellsB7H3geneexpressio...
目的:克隆人B7-H3(CD276)基因的完全编码区序列,在毕赤酵母中表达B7-H3重组蛋白并纯化.方法:应用RT-PCR从人肺癌A549细胞中克隆B7-H3基因的完全编码区序列并在3'端加入6×His标签基因,克隆于毕赤酵母表达载体pPIC9K中,构建表达质粒pPIC9K/B7-H3,以该质粒转染酵母菌株GS115,在含有不同浓度遗传霉素(G418)的YPD平...
H3 eradicated large tumors.Combined therapy enhanced apoptosis of tumor cells and reduced the density of tumor blood vessels.Conclusion As_2O_3 reduces vessel density,and enhances B7-H3-mediated immunotherapy.Strategies targeting B7-H3 gene immunotherapy and As_2O_3 have therapeutic potential in ...