B7-H3 expression was quantified by RNA sequencing and by IHC on pediatric PDX microarrays. We tested the safety and efficacy of m276-SL-PBD in two stages. Randomized trials of m276-SL-PBD of 0.5 mg/kg on days 1...
在B7H3能发生糖基化修饰的TNBC细胞模型和小鼠移植瘤模型中，作者发现核心岩藻糖类似物2-氟-L-岩藻糖（2F-Fuc）能通过下调B7H3的核心岩藻糖化水平，抑制B7H3蛋白在细胞膜表面的表达，恢复T细胞对肿瘤细胞的免疫攻击作用，增强TNBC肿瘤对PD-L1单抗治疗的敏感性。综上所述，本研究揭示了在TNBC细胞中，高表达的FUT...
The association between B7H3 expression and baseline and tumor factors was tested using the Mantel Haenszel test or two-sample T-test. Overall survival was estimated using the Kaplan-Meier method where survival time was calculated from diagnosis to death (or last follow-up for those last known ...
B7-H3 高表达预示着卵巢癌和肺腺的 OS 较差,前列腺 OS 较好。值得注意的是,在具有已知驱动突变(例如 EGFR 、ESR1 、KRAS、SPOP)或不可成药的治疗靶点(TP53、APC)的肿瘤中检测到高 B7-H3。 B7-H3 作为 T 细胞共刺激/共抑制免疫调节蛋白,一方面能够激发 T 细胞的活性,促进免疫反应;另一方面,在特定情况下又...
[6] Inamura K , Amori G , Yuasa T , et al. Relationship of B7-H3 expression in tumor cells and tumor vasculature with FOXP3+ regulatory T cells in renal cell carcinoma[J]. Cancer Management and Research, 2019, Volume 11:7021-7030. ...
免疫检查点B7-H3表达与结肠癌的预后关系(A three-phase trans-ethnic study reveals B7-H3 expression is a significant and independent biomarker associated with colon cancer overall survival) 内容亮点 B7-H3基因表达与肠癌预后的统计...
Correlation of the B7H3 expression with clinical and histopathological data revealed significantly increased expression of B7H3 in poorly differentiated, non-neural invasive tumors and lower expression in neural invasion and severe anaplastic areas of the tumors. B7H3 expression did not significantly vary...
免疫检查点B7-H3表达与结肠癌的预后关系(A three-phase trans-ethnic study reveals B7-H3 expression is a significant and independent biomarker associated with colon cancer overall survival) 内容亮点 B7-H3基因表达与肠癌预后的统计学关联在多个既往研究中结论并不一致。本研究利用TCGA数据库(n=433)、GEO数据...
B7-H3 is a new member of the B7 ligand family and regulates T-cell responses in various conditions. However, the role of B7-H3 in tumour immunity is largely unknown. The purpose of this study was to evaluate the clinical significance of B7-H3 expression
OncoTargets and Therapy Dovepress open access to scientific and medical research Open Access Full Text Article Original Research B7-H3 expression in breast cancer and upregulation of VEGF through gene silence Jing Sun1 Yun-Di Guo1 Xiao-Ning Li1 Yang-Qin Zhang1 Li Gu1 Ping-Ping Wu1 Guang-...