B7-H3 expression was quantified by RNA sequencing and by IHC on pediatric PDX microarrays. We tested the safety and efficacy of m276-SL-PBD in two stages. Randomized trials of m276-SL-PBD of 0.5 mg/kg on days 1...
B7-H3 expression in colorectal cancer: Nuclear localization strongly predicts poor outcome in colon cancer. Int J Cancer. 2012.Ingebrigtsen VA, Boye K, Tekle C, Nesland JM, Flatmark K and Fodstad O. B7-H3 expression in colorectal cancer: Nuclear localization strongly predicts poor outcome in ...
在B7H3能发生糖基化修饰的TNBC细胞模型和小鼠移植瘤模型中，作者发现核心岩藻糖类似物2-氟-L-岩藻糖（2F-Fuc）能通过下调B7H3的核心岩藻糖化水平，抑制B7H3蛋白在细胞膜表面的表达，恢复T细胞对肿瘤细胞的免疫攻击作用，增强TNBC肿瘤对PD-L1单抗治疗的敏感性。综上所述，本研究揭示了在TNBC细胞中，高表达的FUT...
[6] Inamura K , Amori G , Yuasa T , et al. Relationship of B7-H3 expression in tumor cells and tumor vasculature with FOXP3+ regulatory T cells in renal cell carcinoma[J]. Cancer Management and Research, 2019, Volume 11:7021-7030. [7] Majzner R G , Theruvath J L , Nellan A ...
[10] Veenstra R G, Flynn R, Kreymborg K,et al. B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality [J]. Blood, 2015, 125(21): 3335-3346. [11] Hofmeyer K A, Ray A, Zang X. The contrasting role of B7-H3 [J]. Procee...
Moreover, B7-H3 in primary tumors was positively correlated with their respective expression at metastatic sites (蟻 = 0.631; p < 0.001). No significant relationships between B7-H4 and PD-L1 and survival were observed; however, B7-H3 overexpression in primary tumors was significantly related to...
Correlation of the B7H3 expression with clinical and histopathological data revealed significantly increased expression of B7H3 in poorly differentiated, non-neural invasive tumors and lower expression in neural invasion and severe anaplastic areas of the tumors. B7H3 expression did not significantly vary...
免疫检查点B7-H3表达与结肠癌的预后关系(A three-phase trans-ethnic study reveals B7-H3 expression is a significant and independent biomarker associated with colon cancer overall survival) 内容亮点 B7-H3基因表达与肠癌预后的统计...
Unexpectedly, B7-H3 was expressed in the nucleus in 30% of the tumors. The nuclear localization was confirmed by Western immunoblotting of subcellular fractions. Importantly, in colon cancer, nuclear B7-H3 expression was independently and significantly associated with reduced metastasis-free, disease-...
acta neuropathol commun (2021) 9:59 https://doi.org/10.1186/s40478-021-01167-w RESEARCH Open Access The expression of B7‑H3 isoforms in newly diagnosed glioblastoma and recurrence and their functional role Marina Digregorio1†, Natacha Coppieters1†, Arnaud Lombard1,2, ...