[14] MacGregor H L, Sayad A, Elia A, et al. High expression of B7-H3 on stromal cells defines tumor and stromal compartments in epithelial ovarian cancer and is associated with limited immune activation[J].J Immunothe...
B7-H3 expression has been found to be aberrantly upregulated in many different cancer types, and an association between B7-H3 expression and poor prognosis has been established. Immunotherapy targeting B7-H3 through different approaches has been developing rapidly, and many ongoing clinical trials are...
近日，中山大学肿瘤防治中心邓蓉/朱孝峰/唐军合作在Nature Communications发文题为FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer的研究成果。该研究揭示B7H3蛋白的N-聚糖核心岩藻糖基化修饰介导TNBC免疫逃逸发生的新机制；明确靶向干预B7H3蛋白核心岩藻糖...
近日,中山大学肿瘤防治中心邓蓉/朱孝峰/唐军合作在Nature Communications发文题为FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer的研究成果。该研究揭示B7H3蛋白的N-聚糖核...
Membranous staining of the tumor cells was scored and statistical analyses were performed to assess the correlation between B7-H3 expression and treatment outcome. Results B7-H3 expression was absent in 31% of patients, while 33.3% had a score of 1+, 31% had 2+, and 4.8% had 3+. High ...
Unexpectedly, B7-H3 was expressed in the nucleus in 30% of the tumors. The nuclear localization was confirmed by Western immunoblotting of subcellular fractions. Importantly, in colon cancer, nuclear B7-H3 expression was independently and significantly associated with reduced metastasis-free, disease-...
Depletion of B7-H3 in breast cancer significantly inhibits the cancer stem cells. By immunoprecipitation and mass spectrometry, we found that B7-H3 is associated with the major vault protein (MVP) and activates MEK through MVP-enhancing B-RAF and MEK interaction. B7-H3 expression increases stem ...
Clinical importance of B7-H3 expression in human pancreatic cancerYamatoI.ShoM.NomiT.AkahoriShimadaK.HottaingentaconnectBRITISH JOURNAL OF CANCERYamato I, Sho M, Nomi T, Akahori T, Shimada K, Hotta K, Kanehiro H, Konishi N, Yagita H, Nakajima Y (2009) Clinical importance of B7-H3 ...
Background We have previously reported overexpression of the immunoregulatory protein B7-H3 in colorectal cancer and that nuclear expression predicted poor outcome in colon cancer patients. The present study was performed to examine the prognostic role of B7-H3 in an independent colorectal cancer cohort...
We have previously reported overexpression of the immunoregulatory protein B7-H3 in colorectal cancer and that nuclear expression predicted poor outcome in colon cancer patients. The present study was performed to examine the prognostic role of B7-H3 in