近日，中山大学肿瘤防治中心邓蓉/朱孝峰/唐军合作在Nature Communications发文题为FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer的研究成果。该研究揭示B7H3蛋白的N-聚糖核心岩藻糖基化修饰介导TNBC免疫逃逸发生的新机制；明确靶向干预B7H3蛋白核心岩藻糖...
[14] MacGregor H L, Sayad A, Elia A, et al. High expression of B7-H3 on stromal cells defines tumor and stromal compartments in epithelial ovarian cancer and is associated with limited immune activation[J].J Immunothe...
In primary breast cancers, B7-H3 expression significantly correlated with higher tumour grades and aggressive breast cancer subtypes, as well as poorer 5-year survival outcomes. Subcellular localisation of B7-H3 impacted breast cancer-specific survival, with cytoplasmic staining also correlating with a ...
L.T. Nguyen, P.S. OhashiHigh expression of b7-h3 on stromal cells defines tumor and stromal compartments in epithelial ovarian cancer and is associated with limited immune activationJ. Immunother. Cancer, 7 (1) (2019),
4 Liu, C. et al. B7-H3 expression in ductal and lobular breast cancer and its association with IL-10.Molecular medicine reports7, 134-138, doi:10.3892/mmr.2012.1158 (2013). 5 Sanmamed, M. F. & Chen, L. A...
[4]Immune checkpoint of B7-H3 in cancer: from immunology to clinical immunotherapy. J Hematol Oncol 15, 153 (2022). doi.org/10.1186/s13045- [5]Pan-cancer associations of B7-H3 (CD276) transcriptional expression across human malignancies.. JCO 41, 2624-2624(2023).DOI:10.1200/JCO.2023.41....
cancer immunotherapy. B7-H3 has been shown to play an inhibitory role in T cell activation and proliferation, participate in tumor immune evasion and influence both the immune response and tumor behavior through different signaling pathways. B7-H3 expression has been found to be aberrantly up...
B7-H3 is a new member of the B7 ligand family and regulates T-cell responses in various conditions. However, the role of B7-H3 in tumour immunity is largely unknown. The purpose of this study was to evaluate the clinical significance of B7-H3 expression
Relationship of B7-H3 expression in tumor cells and tumor vasculature with FOXP3+ regulatory T cells in renal cell carcinoma[J]. Cancer Management and Research, 2019, Volume 11:7021-7030. [7] Majzner R G , Theruvath J L , Nellan A , et al. CAR T cells targeting B7-H3, a Pan-...
BMC Cancer 2014, 14:602 http://www.biomedcentral.com/1471-2407/14/602 RESEARCH ARTICLE Open Access B7-H3 expression in colorectal cancer: associations with clinicopathological parameters and patient outcome Vibeke A Ingebrigtsen1,2*, Kjetil Boye1,3, Jahn M Nesland2,4, Arild Nesbakken2,6, ...