在肾透明细胞癌中,B7-H3可以上调血管内皮生长因子(vascular endothelial growth factor,VEGF)和人血管生成素受体酪氨酸激酶-2(human angiopoietin receptor tyrosine kinase-2,Tie-2),促进肿瘤内新生血管生成及肿瘤生长[15]。 3.4 本研究...
We have previously reported the following: 1) murine B7-H3 specifically bound to Triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2, TREML2), a member of the TREM family of receptors; and 2) the B7-H3:TLT-2 pathway up-regulated T cell responses. However, ...
另有研究指出,B7-H3 可使胰腺癌细胞 Toll样受体 4(Toll like receptor 4,TLR4)/核因子-κB(nuclear factor-κB,NF-κB)通路激活,上调其下游血管内皮生长因子(vascular endothelial growth factor,VEGF)和 IL-8 的表达,提高胰腺癌细胞...
人B7-H3蛋白以跨膜亚型或可溶亚型存在。跨膜B7-H3是由316个氨基酸组成的I型跨膜蛋白，分子量约为 45-66 kDa，由胞外域、跨膜域和短胞内域组成。根据其胞外结构域，B7-H3 存在两种亚型。一是4IgB7-H3（4Ig VCVC），其包含两对相同的IgV样和IgC样结构域；二是2IgB7-H3（2Ig VC），其包含单对IgV样...
[8] Du H , Hirabayashi K , Ahn S , et al. Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 Via Chimeric Antigen Receptor T Cells[J]. Cancer Cell, 2019, 35: 221-237. [9] Kramer K , Kushner B H , Modak S , et al. Compartmental intrathecal radi...
^Ding M, Liao H, Zhou N, Yang Y, Guan S, Chen L. B7-H3-Induced Signaling in Lung Adenocarcinoma Cell Lines with Divergent Epidermal Growth Factor Receptor Mutation Patterns. Biomed Res Int. 2020 Dec 24;2020:8824805.
T cell receptor BTN2A1: Butyrophilin subfamily 2 member A1 MICA/B: MHC class I-related chain proteins A and B CAR: Chimeric antigen receptor PBMCs: Peripheral blood mononuclear cells PTCs: Patient-derived tumor cell clusters EGFRt: Epidermal growth factor receptor RNA-Seq: RNA sequen...
描述 B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell prolifera...
描述 B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell prolifera...
Receptor B7-H3潜在受体 目前来说对B7-H3阻断抗体开发重视仍然相当有限,最可能是由于其受体未知。TLT-2,IL20RA和PLA2R1都是B7-H3受体的候选基因。图2描绘了B7-H3受体可能存在的结构、生物学功能及相互作用。 图2 B7-H3及其受体的结构、分布、相互作用和生物学功能。