[5]Pan-cancer associations of B7-H3 (CD276) transcriptional expression across human malignancies.. JCO 41, 2624-2624(2023).DOI:10.1200/JCO.2023.41.16_suppl.2624 [6]百济神州实体瘤管线官网https://www.beigenemedical.com/pipeline-pdfs/May_2024/BeiGene%20Clinical%20Static%20Pipeline_Global_May%2...
[6]X Sun,et al. Mouse B7-H3 induces antitum or immunity. Gene Therapy (2003),10, 1728–1734 [7]Theodoros Michelakos, et al. B7-H3 targeted antibody-based immunotherapy of malignant diseases. Expert Opinion on Biological Therapy, https://doi....
T细胞:B7-H3在免疫系统中可能发挥双重作用。一方面,B7-H3作为一种共刺激分子,对CD4+和CD8+细胞具有共刺激作用,诱导细胞免疫,并在T细胞受体信号传导下选择性增强干扰素-γ(IFNG)的产生。 另一方面,在人类和小鼠中的实验证明,B7-H3也具有共抑制作用[10],它可以抑制Treg细胞,从而使肿瘤逃逸免疫反应。这可能与NFAT、N...
[6]X Sun,et al. Mouse B7-H3 induces antitum or immunity. Gene Therapy (2003),10, 1728–1734 [7]Theodoros Michelakos, et al. B7-H3 targeted antibody-based immunotherapy of malignant diseases. Expert Opinion on Biological Therapy, https://doi.org/10.1080/14712598.2021.1862791 [8] Jose R ...
此外,我们还观察到该转录本的3’utr含有mir29 microrna的靶位点,并且该蛋白的表达与mir29水平呈负相关,这表明mir29对该基因产物的表达具有调节作用。另外,已经发现该基因编码不同亚型的剪接转录变体。[由RefSeq提供,2011年9月] The protein encoded by this gene belongs to the immunoglobulin superfamily, and ...
Patients with relapsed pediatric solid malignancies have few therapeutic options, and many of these patients die of their disease. B7-H3 is an immune checkpoint protein encoded by theCD276gene that is overexpressed in many...
Expressed gene: 4ig-B7H3 Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) Freeze Medium: 90% FBS+10% DMSO Culture Medium: DMEM+10%FBS+ 2 μg/ml puromycin Mycoplasma Testing: Negative Storage: Liquid nitrogen III...
前列腺癌是男性癌症发病和死亡的主要原因,尽管几乎所有前列腺癌患者都对雄激素剥夺疗法有反应,但反应持续时间从数月到数年不等,随后发展为去势抵抗前列腺癌(CRPC),此时具有高转移率和死亡率,肿瘤抑制。
The CHO/Human B7-H3 (4Ig) Stable Cell Line was engineered to express the receptor full length human B7-H3 (4Ig) (Gene ID: 80381), used to mimic cancer target cells. Surface expression of human B7-H3 (4Ig) was confirmed by flow cytometry. 应用说明(Application) Useful for cell-based ...
Gene Symbol CD276 Gene ID (NCBI) 80381 RRID AB_2073577 Conjugate Unconjugated Form Liquid Purification Method Antigen affinity purification Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Storage Conditions Store at -20°C. Stable for one year after shipment. Aliquoting is ...