一抗稀释比:Bax(1:1000)、Bcl-xl(1:1000)、Bak(1:1000)、总caspase 3(1:1000)、裂解caspase 3(1:1000)、HMGB1(1:1000)、B7-H3(1:1000)、总Stat1(1:1000)、磷酸化Stat1(1:1000)、GAPDH(1:1000)、β-actin(1:1000);二抗稀释比1:2000。采用化学
此外,我们还观察到该转录本的3’utr含有mir29 microrna的靶位点,并且该蛋白的表达与mir29水平呈负相关,这表明mir29对该基因产物的表达具有调节作用。另外,已经发现该基因编码不同亚型的剪接转录变体。[由RefSeq提供,2011年9月] The protein encoded by this gene belongs to the immunoglobulin superfamily, and ...
B7-H3 General Information: B7-H3 Protein, Antibody, and GeneB7-H3 基本信息 官方名 CD276 官方全称 CD276 molecule HGNC ID HGNC:19137 别称 B7H3, B7-H3, B7RP-2 位点类型 gene with protein product 染色体位置 15q24.1 基因家族 CD molecules V-set domain containing C2-set domain containing H...
[6]百济神州实体瘤管线官网beigenemedical.com/pipe [7]A novel B7-H3 x CD3 bispecific T-cell engager for the treatment of B7-H3 tumors..+ JCO 42, e14509-e14509(2024).DOI:10.1200/JCO.2024.42.16_suppl.e14509 [8]国内首创!爱思迈自研B7-H3/CD3双抗临床试验申请获CDE正式受理 管线推进 [9]Enob...
[6]X Sun,et al. Mouse B7-H3 induces antitum or immunity. Gene Therapy (2003),10, 1728–1734 [7]Theodoros Michelakos, et al. B7-H3 targeted antibody-based immunotherapy of malignant diseases. Expert Opinion on Biological Therapy, https://doi....
Patients with relapsed pediatric solid malignancies have few therapeutic options, and many of these patients die of their disease. B7-H3 is an immune checkpoint protein encoded by theCD276gene that is overexpressed in many...
We investigated thefunction of the B7 family member B7-H3 (also known as B7RP-2) by gene targeting. B7-H3 inhibited T cell proliferation mediated by antibody to T cell receptor or allogeneic antigen-presenting cells. B7-H3-deficient mice developed more severe airway inflammation than did wild...
Expressed gene:4ig-B7H3 Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) Freeze Medium:90% FBS+10% DMSO Culture Medium:RPMI-1640+10%FBS+ 2 μg/ml puromycin Mycoplasma Testing:Negative ...
Expressed gene:4ig-B7H3 Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) Freeze Medium:90% FBS+10% DMSO Culture Medium:DMEM+10%FBS+ 2 μg/ml puromycin Mycoplasma Testing:Negative ...
The CHO/Human B7-H3 (4Ig) Stable Cell Line was engineered to express the receptor full length human B7-H3 (4Ig) (Gene ID: 80381), used to mimic cancer target cells. Surface expression of human B7-H3 (4Ig) was confirmed by flow cytometry. 应用说明(Application) Useful for cell-based ...