【Key words】PDL1；Stable expression；B16F10cell lines 细胞程序性死亡配体1（Programmed cell death ligand1，PD－L1）属于B7超家族成员，主要表达在B 细胞、巨噬细胞等抗原提呈细胞表面［1］。PD－L1的受体为PD－1，其胞质区含有免疫受体酪氨酸抑制基序，为抑制性的受体。静止的T细胞不表达PD－1受体，T细胞...
Expression of Programmed Death-Ligand 1 (PD-L1) is also reduced, declining from 1.34 卤 0.23 ng/mg protein (n=5) to 0.50 卤 0.05 ng/mg protein (n=6) following ARSB treatment. Inverse to the effect on galectin-3, SHP2, the ubiquitous non-receptor tyrosine phosphatase (PTPN11), binds...
A 13-fold increase in cyclin-dependent kinase inhibitor 2A was observed with the combinational ATRA + SM treatment, while suppressing the programmed death ligand 1 (PD-L1) expression by 0.5-fold. Conclusion: Combinational ATRA and SM therapy could be a promising therapeutic ...
Neospora caninum treatment significantly increased the mRNA expression levels of IL-12, IFN-γ, IL-2, IL-10, TNF-α, and PD-L1 in the TME, and IL-12 and IFN-γ in the spleen of tumor-bearing mice (P<0.05). An increase in the infiltration of CD8 Conclusion:Neospora caninum ...
Methods: The immune checkpoint PD-L1 was analyzed using qPCR, immunoblots, and immunofluorescence. Melanoma sensitivity towards T cells was investigated via cytotoxicity, cell viability, and IL-2 assays employing CTLL-2 cells. Results: Maltol was found to reduce melanin co...
And with these changes, the mRNA expression levels of IL-12, IFN-纬, IL-2, IL-10, TNF-伪 and PD-L1 in tumor microenvironment and IL-12, IFN-纬, IL-2 in spleen were also significantly increased (P<0.05). Altogether, our results indicate that a sufficient amountN. caninumtachyzoites...
Neospora caninum treatment significantly increased the mRNA expression levels of IL-12, IFN-纬, IL-2, IL-10, TNF-伪, and PD-L1 in the TME, and IL-12 and IFN-纬 in the spleen of tumor-bearing mice (P<0.05). An increase in the infiltration of CD8 Conclusion:Neospora caninum ...
2.2. Zerumbone Suppresses Gene Expression of Melanogenesis Transcription Factor, MITF, and Its Target Genes in G361 Human Melanoma Cells Endothelin-1 and SCF signaling have been reported to play essential roles in melanogenesis in human melanocytes and in several subtypes of melanoma [3,14–16]. ...
Pp-EE promoted the expression of hyaluronic acid (HA) synthesis-related enzymes and suppressed the expression of HA degradation-related enzymes in keratinocytes, so it may increase skin hydration. Pp-EE also showed inhibitory effects on the production and secretion of melanin in melanocytes. In a ...