在人体免疫系统中,记忆B细胞(memory B cells,特指那些已发生类别转换并表达CD27标记的B细胞)的数量普遍超过外周血中的初始B细胞,尤以老年人群为甚。这一发现,加之记忆B细胞所展现出的显著稳定性(可维持至少数十年之久)及其在体外实验中相较于初始B细胞更为迅速的激活动力学特性,引发了学界对其功能的深入思考。
some memory B cells differentiate into plasma cells without T cell help (T cell-independent, TI, response). The remaining memory B cells respond through interaction with
2024年6月17日,来自清华大学医学院、清华大学基础医学院、清华大学免疫学研究所的祁海教授团队在Immunity发表了题为High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function的研究...
在人体免疫系统中,记忆B细胞(memory B cells,特指那些已发生类别转换并表达CD27标记的B细胞)的数量普遍超过外周血中的初始B细胞,尤以老年人群为甚。这一发现,加之记忆B细胞所展现出的显著稳定性(可维持至少数十年之久)及其在体外实验中相较于初始B细胞更为迅速的激活动力学特性,引发了学界对其功能的深入思考。
1. Memory B Cells in Multiple Sclerosis:Emerging Players in Disease Pathogenesis.FrontImmunol.2021; 12: 676686. 培训推荐 上海交通大学-新药临床试验高级研修班 识别微信二维码,添加抗体圈小编,符合条件者即可加入抗体圈微信群! 请注明:姓名+研究方向!
memory B cellsantibody‐secreting cellplasma cellplasmablastlong‐livedhumoral responseantibodyimmunizationvaccinationhumanHistorical measurements of human vaccine immunity have included neutralizing antibody. These serologic immune correlates are based on the "B-cell memory response" to guarantee immediate ...
Recent advances in studies of immune memory in mice and humans have reinforced the concept that memory B cells play a critical role in protection against repeated infections, particularly from variant viruses. Hence, insights into the development of high-quality memory B cells that can generate broa...
记忆B细胞(Memory B Cell):记忆B细胞的寿命很长,再次暴露抗原时,记忆B细胞可立即生成对抗其抗原的抗体。随着再次暴露于外源抗原,记忆B细胞立即重新分化为活化B细胞,并能够进一步分化为能分泌抗体的浆细胞。记忆B细胞一般认为是CD27+,不过也存在CD27-IgD-的同型转换亚型。
2024年6月17日,清华大学祁海团队在Immunity在线发表题为“High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function”的研究论文,该研究发现第一个专门维持记忆B细胞再应答能力的关键调控因子ZFP318...
Fig.5.1 Differentiation of memory B cells during the primary response. Memory B cells are developed through two different pathways. Antigen-specific B cells are primed by antigen recognition and further activated by the secondary signal from cognate T cells. Following B-T interaction, some B cells...