Memory B cells. Kurosaki T,Kometani K,Ise W. Nature Reviews Immunology . 2015Kurosaki T, Kometani K, Ise W. 2015. Memory B cells. Nature Reviews. Immunology 15:149-159. doi: 10.1038/nri3802.Kurosaki T, Kometani K, Ise W. 2015. Memory B cells. Nat Rev Immunol 15:149 -159. ...
Surviving a single infection often results in lifelong immunity to the infecting pathogen. Such protection is mediated, in large part, by two main B cell memory ‘walls’ — namely, long-lived plasma cells and memory B cells. The cellular and molecular processes that drive the production of lo...
B cell memory is formed by long-lived plasma cells spontaneously secreting antibodies in the bone marrow and by memory B cells differentiating into plasma cells upon reencounter with their cognate antigen. From: Fetal and Neonatal Physiology (Fifth Edition), 2017 ...
在人体免疫系统中,记忆B细胞(memory B cells,特指那些已发生类别转换并表达CD27标记的B细胞)的数量普遍超过外周血中的初始B细胞,尤以老年人群为甚。这一发现,加之记忆B细胞所展现出的显著稳定性(可维持至少数十年之久)及其在体外实验中相较于初始B细胞更为迅速的激活动力学特性,引发了学界对其功能的深入思考。
2024年6月17日,来自清华大学医学院、清华大学基础医学院、清华大学免疫学研究所的祁海教授团队在Immunity发表了题为High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function的研究...
Memory B cells found in human patients infected with Mycobacterium tuberculosis include IgD+ CD27+ and IgM+ CD27+ subsets. In addition, expansion of atypical memory B cells characterized by the lack of CD27 expression and by inability to respond to antigen-induced re-activation is documented in...
在人体免疫系统中,记忆B细胞(memory B cells,特指那些已发生类别转换并表达CD27标记的B细胞)的数量普遍超过外周血中的初始B细胞,尤以老年人群为甚。这一发现,加之记忆B细胞所展现出的显著稳定性(可维持至少数十年之久)及其在体外实验中相较于初始B细胞更为迅速的激活动力学特性,引发了学界对其功能的深入思考。
2024年6月17日,清华大学祁海团队在Immunity在线发表题为“High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function”的研究论文,该研究发现第一个专门维持记忆B细胞再应答能力的关键调控因子ZFP318...
在人体免疫系统中,记忆B细胞(memory B cells,特指那些已发生类别转换并表达CD27标记的B细胞)的数量普遍超过外周血中的初始B细胞,尤以老年人群为甚。这一发现,加之记忆B细胞所展现出的显著稳定性(可维持至少数十年之久)及其在体外实验中相较于初始B细胞更为迅速的激活动力学特性,引发了学界对其功能的深入思考。
two waves of memory B-cell differentiation occurs. In the early phase of reinfection, some memory B cells differentiate into plasma cells without T cell help (T cell-independent, TI, response). The remaining memory B cells respond through interaction with T cells (T cell-dependent, TD, respon...