在经历了一系列突变、筛选和扩增过程后,成熟的B细胞分化为产生大量分泌型抗体的浆细胞(plasma cells)或记忆B细胞(memory B cell)。 淋巴结是B细胞成熟的主要器官(还有一个比较主要的器官是脾脏,结构和淋巴结类似)。B细胞从血管中流入,通过高内皮小静脉HEV(High endothelial venules)进入淋巴结;与此同时T细胞由...
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在人体免疫系统中,记忆B细胞(memory B cells,特指那些已发生类别转换并表达CD27标记的B细胞)的数量普遍超过外周血中的初始B细胞,尤以老年人群为甚。这一发现,加之记忆B细胞所展现出的显著稳定性(可维持至少数十年之久)及其在体外实验中相较于初始B细胞更为迅速的激活动力学特性,引发了学界对其功能的深入思考。
Surviving a single infection often results in lifelong immunity to the infecting pathogen. Such protection is mediated, in large part, by two main B cell memory ‘walls’ — namely, long-lived plasma cells and memory B cells. The cellular and molecular p
记忆B细胞(Memory B Cell):记忆B细胞的寿命很长,再次暴露抗原时,记忆B细胞可立即生成对抗其抗原的抗体。随着再次暴露于外源抗原,记忆B细胞立即重新分化为活化B细胞,并能够进一步分化为能分泌抗体的浆细胞。记忆B细胞一般认为是CD27+,不过也存在CD27-IgD-的同型转换亚型。
cells is critically dependent on CD40 of the B cell and CD40L expressed by T cells and FDCs. Inactivation of the CD40 or CD40L genes by targeted mutation in the murine germline or by accidental mutation in human subjects leads to a hyper-IgM syndrome and a general lack of B-cell memory....
aThe struggle to buy Toyota next year 明年买丰田的奋斗[translate] aProliferation of B cells, plasma cell differentiation, immunoglobulin E and Msecretion, and production of memory B cells are compromised, while 1,25-(OH)2D3 induces apoptosis in B cells 正在翻译,请等待...[translate]...
3) memory B-lymphocytes 记忆B淋巴细胞4) Memory cells 记忆细胞 1. In this paper,the distribution of memory cells produced by them is compared. 本文对二者产生的记忆细胞分布进行比较研究,指出二者在分类性能上的差别来自记忆细胞分布。 2. An model consisted of memory cells,matured cells,and ...
Humans respond to foreign antigen by generating plasma Abs and memory B cells (MBCs). The Ab response then declines, sometimes to below the limit of detection. In contrast, MBCs are generally thought to be long-lived. We tested and compared Plasmodium falciparum (Pf)-specific Ab and MBC resp...