在人体免疫系统中,记忆B细胞(memory B cells,特指那些已发生类别转换并表达CD27标记的B细胞)的数量普遍超过外周血中的初始B细胞,尤以老年人群为甚。这一发现,加之记忆B细胞所展现出的显著稳定性(可维持至少数十年之久)及其在体外实验中相较于初始B细胞更为迅速的激活动力学特性,引发了学界对其功能的深入思考。
相较于记忆B细胞,幼稚B细胞的IgD和CD21表达量较高,CD27表达量较低。 记忆B细胞(Memory B Cell):记忆B细胞的寿命很长,再次暴露抗原时,记忆B细胞可立即生成对抗其抗原的抗体。随着再次暴露于外源抗原,记忆B细胞立即重新分化为活化B细胞,并能够进一步分化为能分泌抗体的浆细胞。记忆B细胞一般认为是CD27+,不过也存...
在经历了一系列突变、筛选和扩增过程后,成熟的B细胞分化为产生大量分泌型抗体的浆细胞(plasma cells)或记忆B细胞(memory B cell)。 淋巴结是B细胞成熟的主要器官(还有一个比较主要的器官是脾脏,结构和淋巴结类似)。B细胞从血管中流入,通过高内皮小静脉HEV(High endothelial venules)进入淋巴结;与此同时T细胞由...
Wrammert等制备的抗H1N1抗体是从外周血中分离浆细胞(Plasma cells)获得;Morris等则通过分离外周血单个记忆B细胞(Memory B cells)得到抗HIV抗体;Wardemann等为研究人自身反应抗体的结构和规律,从正常人骨髓中分离前B细胞制备自身反应抗体。 在样品丰富的情况下,为提高特异性抗体得...
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Surviving a single infection often results in lifelong immunity to the infecting pathogen. Such protection is mediated, in large part, by two main B cell memory ‘walls’ — namely, long-lived plasma cells and memory B cells. The cellular and molecular p
Memory B cellsresemblenaïve B cellsin their small size and general morphology but carry differentsurfacemarkers and have a longer life span. As the primary response terminates,memory B cellsoften take up residence in a body location where the antigen might next be expected to attack. For examp...
Memory B cells are generated upon stimulation with antigen presented by follicular dendritic cells in the peripheral lymphoid tissues. This process typically involves class-switch recombination and somatic hypermutation and it can be dependent or independent on germinal centers or T cell help. The ...
Recent advances in studies of immune memory in mice and humans have reinforced the concept that memory B cells play a critical role in protection against repeated infections, particularly from variant viruses. Hence, insights into the development of high-quality memory B cells that can generate broa...