Switched memory B cells expressed more IL-6 and IL-12 mRNA than other subpopulations, but differences in respective protein levels were not significant. Moreover, we found that switched memory B cell transfer resulted in increased alveolar bone loss and periodontal osteoclastogenesis. Moreover, ...
The mechanisms of secondary changes in antibody repertoires remain unclear. McHeyzer-Williams and colleagues define the stages of reentry of class-switched memory B cells into germinal centers to remodel existing antibody specificities. Effective vaccine
Switched-memoryBcellsremodelBcellreceptorswithin secondarygerminalcenters LouiseJ.McHeyzer-Williams # ,PierreJ.Milpied ## ,ShinjiL.Okitsu § ,andMichaelG. McHeyzer-Williams ‡ DepartmentofImmunologyandMicrobialScienceTheScrippsResearchInstitute,LaJollaCA 92037 # Theseauthorscontributedequallytothiswork. Abst...
switched-memory b cells remodel b cell receptors within secondary germinal centers hhs public access author manuscript Effective vaccines induce high-affinity memory B cells and durable antibody responses through accelerated mechanisms of natural selection. Secondary change... LJ Mcheyzer-Williams,PJ Milpi...
Immune competence and switched memory B cells in common variable immunodeficiency Common variable immunodeficiency (CVID) is presumed to be a heterogenous group of disorders with potentially separate etiologies. Memory B cell subsets, ch... J Ko,R Lin,C Cunningham-Rundles - 《Clinical Immunology》 ...
Interestingly, current smokers had higher percentages of (class-switched) memory B cells than ex-smokers and never smokers, irrespective of COPD./p pThis increase in (class-switched) memory B cells in current smokers is intriguing and suggests that smoke-induced neo-antigens may be constantly ...
Furthermore, the ITT improves the reactivation of memory B cells in a T-cell-independent manner. Our results show that ITT signalling is essential for B-cell memory in vivo. Results ITT phosphorylation enhances BCR-proximal signalling. To investigate the function of the ITT signalling motif in ...
Compared to memory B cells, naive B cells express more surface BCRs, which interact better with BAFFR than IgG or IgA, thus allowing stronger responses to BAFF. As ablation of BAFFR in naive and memory B cells causes cell death independent of BAFF-induced signaling, BAFFR seems to act also...
Multi-source/drain Spatial Wavefunction Switched (SWS) field-effect transistors (FETs) are configured to serve as 1-bit and 2-bit static random access memory (SRAM) and dynamic random access memory (DRAM) cells. The SWS-FET transport channel comprises of multiple asymmetric coupled wells which ...
Cite this protocol Frasca, D., Diaz, A., Blomberg, B.B. (2015). Activation-Induced Cytidine Deaminase and Switched Memory B Cells as Predictors of Effective In Vivo Responses to the Influenza Vaccine. In: Shaw, A. (eds) Immunosenescence. Methods in Molecular Biology, vol 1343. Humana Pres...