The mechanisms of secondary changes in antibody repertoires remain unclear. McHeyzer-Williams and colleagues define the stages of reentry of class-switched memory B cells into germinal centers to remodel existing antibody specificities. Effective vaccine
S.14. Decrease in Class-switched Memory B Cells is Associated with Malignancy in Common Variable Immunodeficiency (CVID)ingentaconnectCLINICAL IMMUNOLOGY -SAN DIEGO- ACADEMIC PRESS-JoshiA.ParkM.HaganJ.BoyceT.LiReedMaddoxD.HartzVolcheckG.Rank
(memory)B-cellpercentagesandhigherTregpercentagesinperipheralbloodthanhealthyindividuals,withasignificantnegativecorrelationbetweenthesecells.Interestingly,currentsmokershadhigherpercentagesof(class-switched)memoryBcellsthanex-smokersandneversmokers,irrespectiveofCOPD.Thisincreasein(class-switched)memoryBcellsincurrent...
Future studies focusing on the presence of these (class switched) memory B cells in the lung, their antigen specificity and their interaction with Tregs are necessary to further elucidate the specific B-cell response in COPD./p 展开 关键词: health policy public policy delivery of health care ...
IgG anti-IgA antibodiesCommon Variable Immunodeficiency (CVID)IgA deficiencyIgA+ B cellsClass-switched CD27pos IgMneg IgDneg memory B cells... Julia Horn and Vojtech Thon and Dana Bartonkova and Ulrich Salzer and Klaus Warnatz and Michael Schlesier and Hans-Hartmut Peter and Bodo Grimbacher - ...
Hu-PNS patients had elevated numbers of regulatory T cells, central memory T cells, class-switched B cells and dendritic cells in their CSF. These findings support the hypothesis that the immune system is locally activated in Hu-PNS, and suggests common etiological pathways between Hu-PNS and ...
The low class-switched memory B cells (CD27+IgMIgD) may serve as a potential biomarker for the need of continued immunoglobulin replacement therapies.doi:10.1007/s12308-020-00415-7Caitlin M. G. McNultySt Paul Allergy and Asthma, St. Paul, USAAvni Y. Joshi...
Accumulation of class switched IgD-IgM- memory B cells in the cerebrospinal fluid during neuroinflammation. J Neuroimmunol 2006;180:33-9.Cepok S, von Geldern G, Grummel V, Hochgesand S, Celik H, Hartung H, et al. Accumulation of class switched IgD-IgM- memory B cells in the ...
In the FSGS patients, the frequency of CD27 + IgD-IgG + class-switched memory B cells negatively correlated with CD38 + IgG + plasmablasts (P = 0.0183, R = -0.3375), serum IgG levels (P = 0.0061, R = -0.4263) and estimated glomerular filtration rate (eGFR) (P = 0.0074, R = -...
class-switched memory B cellsnonprogressive HIV infectionHIV perturbs the functionality of B cells resulting in defective humoral responses. As efficient humoral immune responses are important in controlling HIV-disease progression, we characterized the memory B cell population for its subsets and their ...