The mechanisms of secondary changes in antibody repertoires remain unclear. McHeyzer-Williams and colleagues define the stages of reentry of class-switched memory B cells into germinal centers to remodel existing antibody specificities. Effective vaccine
The accumulation of memory B cells in the CSF was largely due to the recruitment of IgM-IgD- class switched memory B cells. The distribution of IgM+IgD+, IgM-IgD+, IgM+IgD- memory cells and immature cells did not differ significantly between CSF and PB. These findings demonstrate a ...
cellssmokersswitchedperipheralmemoryblood BioMedCentralPage1of11(pagenumbernotforcitationpurposes)RespiratoryResearchOpenAccessResearchIncreasedlevelsof(classswitched)memoryBcellsinperipheralbloodofcurrentsmokersCorry-AnkeBrandsma*1,2,MachteldNHylkema2,MarieGeerlings1,2,WouterHvanGeffen1,DirkjeSPostma1,WimTimens2and...
The negative correlation between B cells and Tregs in blood is in line with previously published observations that Tregs can suppress B cells. Future studies focusing on the presence of these (class switched) memory B cells in the lung, their antigen specificity and their interaction with Tregs ...
Cd27+IgG + Class Switched Memory B Cells Show the Strongest Association with Clinical Complication In Common Variable Immunodeficiency 来自 ResearchGate 喜欢 0 阅读量: 21 作者:S Chishimba,AH Grashoff,MVD Burg,GJA Driessen 摘要: The immune system is made of an intricate, yet well-organized, ...
The presence of these class-switched thymic B cells is dependent on cognate interactions with thymocytes and activation-induced cytidine deaminase (AID). They possess a distinct B cell receptor repertoire with a massive expansion of autoreactive specificities, suggesting that autoreactive B cells are ...
B-cell depletive therapies have beneficial effects in patients suffering from rheumatoid arthritis. Nevertheless, the role of B cells in the pathogenesis o... AS Rouzière,C Kneitz… - 《Arthritis Research & Therapy》 被引量: 136发表: 2005年 Blood memory B cells are disturbed and predict the...
In six of eight patients, we identified peripheral CD27(+)IgD(-) memory B cells, CD27(hi)CD38(hi) plasma cells/plasmablasts, or CD27(-)IgD(-) B cells that had an immune connection to the CNS compartment. Pinpointing Ig class-switched B cells as key component of the immune axis ...
CD27(−) B-cells produce class switched and somatically hyper-mutated antibodies during chronic HIV-1 infection. PLoS ONE. 2009; 4 (5):e5427... Cagigi,Alberto,Likun,... - 《Plos One》 被引量: 51发表: 2009年 Identification of Functional Human Splenic Memory B Cells by Expression of ...
Switched current class AB memory cells are known to be performent SI cells. However, designing such optimal cells is a tedious process which reclines on designer experience. Thus, automating the transistor sizing process is a very important step towards being able to rapidly design high performance...