In this article, we highlight the different roles of autophagy in cell death and discuss six of the main autophagy-related cell death modalities, with a focus on the metabolic changes caused by excessive endoplasmic reticulum-phagy (ER-phagy)-induced cell death and the role of mitophagy in aut...
Cell Rep. Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival Nat Commun. Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy Eur J Pharmacol. Malvidin protects against lipopolysaccharide-induced acute liver injury...
In addition, STING1 activation can impair immunotherapy because it is a mediator of IFN-induced cell death of B cells184 or T cells185. Consequently, STING1 inhibitors (Table 1) can alleviate the side effects of STING1 overactivation. Table 1 STING1 activators and inhibitors Full size table ...
As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism. Although there is growing evidence of cell death by autophagy, this type of cell death, often called...
RIPK3 binds to AMPK to trigger autophagy during TNF-induced necroptosis, but TNF disrupts the SNARE complex and inhibits autophagosome–lysosome fusion [92]. There are several questions about these modes of cell death that remain unanswered, including the following: 1. What is the relationship ...
Although these results suggest that autophagy upregulation may be beneficial and pro-survival in certain settings, we also found that — at leastin vitro— Tat-Beclin 1-induced time- and dose-dependent cell death.5This death was blocked by pharmacological or genetic inhibition of autophagy, but ...
【2】Cell Death Dis︱孔慧等揭示P2X7/NLRP3炎症小体通路在早期糖尿病视网膜病变中的作用 【3】Sci Adv︱刘兴国/田梅团队发现药物诱发帕金森综合征中线粒体清除新机制 【4】Front Aging Neurosci︱肠道准备可通过改变菌群组成影响术后谵妄...
6. Gatica D, Lahiri V, Klionsky DJ. Cargo recognition and degradation by selective autophagy. Nat Cell Biol 2018;20:233-242. 7. Pohl C, Dikic I. Cellular quality control by the ubiquitin-proteasome system and autophagy. Science 2019;366:818-822. ...
Though many nanoparticles interact with cells without acute toxic responses, amino-modified polystyrene nanoparticles are known to induce cell death. We have found that by lowering their dose, cell death remains low for several days while, interestingly, cell cycle......
Chitosan-induced programmed cell death in plants Chitosan, CN, or HO caused the death of epidermal cells (EC) in the epidermis of pea leaves that was detected by monitoring the destruction of cell nuclei;... L A Vasil'ev, E V Dzyubinskaya, R A Zinovkin, D B Kiselevsky, N V Loby...