tumor, whereas copper chelators attenuate experimental acute pancreatitis associated with ferroptosis. Taken together, these findings provide new insights into the link between metal stress and autophagy-dependent cell death. Ferroptosis 是一种铁依赖性调节细胞死亡,其特征是不受限制的脂质过氧化和膜损伤。 ...
autophagy seems to determine whether a cell lives or dies [8,9,10]. The roles of autophagy in cell death are mainly classified into autophagy-dependent cell death (ADCD) (or autophagic cell death, ACD)
2023年4月16日,广州医科大学病理生理学教研室、广东省蛋白质修饰与降解重点实验室陈鑫副研究员和刘金保教授团队在Autophagy杂志发表题为"Copper metabolism in cell death and autophagy"的综述文章。作者首先总结了铜离子的关键代谢过程及其在人体生理和疾病中的重要作用,讨论了铜离子如何影响及触发各种类型的细胞死亡(...
Plant lectins in cancer therapeutics: Targeting apoptosis and autophagy-dependent cell deathPlant lectinsCancerAutophagyApoptosisBiomarkerDrug deliveryPlant lectins are non-immunoglobin in nature and bind to the carbohydrate moiety of the glycoconjugates without altering any of the recognized glycosyl ligands. ...
[8,9,10]. The roles of autophagy in cell death are mainly classified into autophagy-dependent cell death (ADCD) (or autophagic cell death, ACD), which depends on the autophagy mechanism, and autophagy-mediated cell death (AMCD), which depends on other modes of cell death. In ADCD, the...
autophagy又叫做Ⅱ型程序性细胞死亡,是指细胞利用溶酶体降解、选择性地清除自身受损、衰老或过剩的生物大分子和细胞器,释放出游离小分子供细胞回收利用的正常动态生命过程。自噬被认为是机体的一种自我保护机制。 二、细胞自噬的三种形式 三、细胞自噬信号通路图 ...
3 Using more stringent genetic criteria to define a causative role of autophagy in cell death, several studies in the past decade have shown that autophagy-dependent cell death occurs under certain experimental conditions.4 Recently, we identified a novel form of autophagy gene-dependent, Na+,K+...
Autophagy and cell death are fundamental cellular processes that play critical roles in the physiology and pathology of multicellular organisms. Autophagy is a conserved housekeeping process utilized by cells to maintain homeostasis by conveying intracel
Autosis, a New Form of Non-Apoptotic Cell Death To investigate cell death in the setting of very high levels of autophagy, we evaluated the effects of an autophagy-inducing peptide, Tat-Beclin 1, on autophagy-dependent cell death. Tat-Beclin 1 is derived from 18 amino acids of the evolutio...