Increasing research evidence indicates that some types of programmed cell death (PCD), including apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis, contributed to asthma pathogenesis, and may become new targets for future asthma treatment. This review briefly discusses the molecular mechanism ...
The role of autophagic cell death, also called type II programmed cell death, is unclear in T cells. Our recent work demonstrated that autophagy is induced in both Th1 and Th2 cells. Both TCR signaling and IL-2 increase autophagy in T cells, and JNK MAP kinases are required for the ...
Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials We also discuss recent examples of the impact of engineered nanoparticles on the three different pathways of programmed cell death. For example, acute expo... 被引量: 0发表: 2012年 editor's choice:Ap...
Is autosis a subtype of autophagic cell death or does all autophagic cell death occur by autosis? Does autosis occur under other pathophysiological conditions? What are the biological and clinical implications of autosis? Programmed cell death is a highly regulated cellular response in metazoans to co...
programmed death. For cell death to be attributed to ADCD,①the autophagic flux must be elevated during cell death;②the cell death process must be reversible via genetic or pharmacological inhibition of autophagy;③the death process depends on at least two autophagy molecules, which prevents ...
Autophagy regulates progression of programmed cell death during petal senescence in Japanese morning glory. Shibuya Kenichi,Yamada Tetsuya,Ichimura Kazuo. Autophagy . 2009Shibuya K,Yamada T,Ichimura K.Autophagy regu-lates progression of programmed cell death during petalsenescence in Japanese morning glory...
Evading programmed cell death is a common event in tumour development. The p53 family member, p73, is a potent inducer of death and a determinant of chemotherapeutic response, but different to p53, is rarely mutated in cancer. Understanding cell death pa
Programmed cell death is a highly regulated cellular response in metazoans to control cell fate following various cellular stresses and/or extrinsic stimuli. Historically, three types of cell death have been identified based on morphological criteria, including Type I (apoptosis), Type II (autophagic ...
Programmed cell death (PCD)鈥攁poptosis, autophagy and programmed necrosis鈥攊s any pathological form of cell death mediated by intracellular processes. Ototoxic drugs, ageing and noise exposure are some common pathogenic factors of sensorineural hearing loss (SNHL) that can induce the programmed ...
Homeostatic and pathological cell death can take diverse forms that, when disrupted, can lead to diseases such as cancer and degenerative conditions. For a long time, cell death was thought to occur through apoptosis, which is a programmed event that often confers an advantage to the organism, ...