In this Review, we discuss the therapeutic potential of autophagy modulators, analyse the obstacles that have limited their development and propose strategies that may unlock the full therapeutic potential of autophagy modulation in the clinic. This is a preview of subscription content, access via ...
There are tables of calories; a useful glossary which defines the technical terms in lay language; a collection of questions and answers that deal with some specific problems; anddoi:10.1001/jama.1964.03070200127045King... King,S Lester - 《Journal of the American Medical Association》 被引量: ...
Our understanding of the process of autophagy and its role in health and diseases has grown remarkably in the last two decades. Early work established autophagy as a general bulk recycling process which involves the sequestration and transport of intracellular material to the lysosome for degradation....
For the upcoming guideline paper, Klionsky winnowed through a mountain of 16,000 papers related to autophagy, many of them on systems other than yeast, and many introducing new terms or methods. The last guidelines, published in 2012, had only half as many authors. Many factors have contribut...
is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited....
In mammalian cells, a well-studied ubiquitin-dependent mitophagy pathway induced by mitochondrial depolarization is regulated by the mitochondrial protein kinase PINK1, which upon activation recruits the ubiquitin ligase parkin. Here, we review mechanisms of mitophagy with an emphasis on posttranslational ...
mitochondrial dysfunction, and an increase in intracellular LIP [94]. Clearly, HO-1 is extremely complex in terms of its tumorigenesis promotion and inhibition, but it may be a viable target for GBM treatment, that is, designing targeted inhibitor of HO-1 “dark” side based on its elevated...
in turn, increases mitochondrial fatty acid availability and β-oxidation.20 Indeed, recent studies have suggested that neuronal free fatty acid availability and its oxida- tion may fulfill the bioenergetic needs in terms to rapid produc- tion of sufficient ATP molecules for neuronal activation and...
A question arises as to whether autophagy has a protective effect or a harmful effect in terms of HIRI. The vast majority of researchers in experimental studies have confirmed that autophagy has a positive hepatoprotective effect, while few have found that autophagy aggravates HIRI. Considering the ...
autophagy induction factors, i.e., the subunits of ULK1 and PI3K complexes, has been revealed as a common mechanism for turning on and off the autophagy process under different cellular contexts. In addition, ubiquitination participates in positive feedback regulations for timely induction of ...