Autophagy - animal Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of...
Through experiments that focus on animal development, fundamental mechanisms that control autophagy and that contribute to disease were elucidated. Studies in embryos revealed specific autophagy molecules that mediate the removal of paternally derived mitochondria, and identified autophagy components that clear...
Macroautophagy core proteins were found in yeast and later in animal models -mice, Drosophila, C. elegans and zebrafish- including ATG13, ATG9, ATG14, ATG10, ATG4, ATG9 and LC3B. Read the blog!
A conditioned autophagy-deficient animal and a disease model animal. Namely, a knockout animal in which the function of a gene causative of autophagy is entirely or partly impaired depending on Cre recombinase; a disease model animal comprising a knockout animal in which the function of a gene...
2024年8月1日,澳门大学沈汉明教授团队在Autophagy上发表文章Spautin-1 promotes PINK1-PRKN-dependent mitophagy and improves associative learning capability in an Alzheimer disease animal model。 作者发现,在线粒体受损伤的情况下,spa...
Using rapamycin to treat animal models of HD, this study was the first to demonstrate that upregulation of autophagy can have a beneficial effect in in vivo models of the disease. CAS PubMed Google Scholar Menzies, F. M. et al. Autophagy induction reduces mutant ataxin-3 levels and ...
Second, differences in the composition of the intestinal microbiota between animal facilities can have a substantial effect on skewing CD4+ T cells responses. In particular, the Clostridium-related segmented filamentous bacteria (SFB) have been shown to drive the emergence of IL-17 and IL-22 ...
The effect of autophagy on the degradation of protein aggregates was investigated further in cell culture and animal models using pharmacological inducers and inhibitors of autophagy (see Tab.4). It was discovered that rapamycin, an inducer of autophagy, leads to the clearance of polyQ/polyA aggreg...
Mice were housed in a specific pathogen-free animal facility under temperatures 22 ± 2 °C) and humidity-controlled (55 ± 5%) conditions with a 12 h light/12 h dark circadian cycle and access to food and water. Animal studies All mouse experiments were conducted according ...
Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease. Neuron 60, 247–257 (2008). Article CAS PubMed PubMed Central Google Scholar Spencer, B. et al. Beclin 1 gene transfer activates autophagy and ameliorates the...