近日,动科学院刘国世教授团队在褪黑素调控自噬与炎症的研究中取得重要进展。相关研究在线发表于国际知名期刊《Autophagy》(最新影响因子11.1;5年影响因子11.8),文章题目为“Effects of AANAT overexpression on the inflammatory responses and autophagy activity in the cellular and transgenic animal levels”( https://...
这可能是由于永生细胞的产能方式是糖酵解而神经细胞的产能方式是氧化磷酸化,两者对于线粒体的依赖程度不同导致引起线粒体自噬的方式不同,神经细胞中可能存在其他通路调控线粒体稳态。 图1 PINK1-PRKN介导的线粒体自噬的体外研究(图源:Han R, et al., Autophagy, 2022) 三、PINK1-PRKN相关的线粒体功能的体内研...
4. 不同实验动物依据体表面积的等效剂量转换表请参考如下网页: http://www.beyotime.com/support/animal-dose.htm Version 2017.11.01 2 / 2 SC5502 SMER28 (Autophagy增强剂) 400-1683301/800-8283301 碧云天/Beyotime http-equiv="content-type"
ACAC通过mTOR信号通路抑制自噬诱导奶牛乳腺上皮细胞氧化应激 (autophagy related 5 homolog, ATG5)和自噬相关因子7(autophagy related 7 homolog, ATG7)的基因表达水平进行定量分析.结果显示,与0 mmol/L ACAC组相比,不同浓度... 高爽,宋倩,董昊,... - 《中国兽医学报》 被引量: 0发表: 2023年 DMSO_A_377041...
In Vivo: SLLN-15 (30mg/kg, PO, 3 times a week) not only inhibits the growth of TNBC in animal model, but also TNBC cell progression to metastases.Overall, oral SLLN-15 reveals a potent anticancer and anti-metastatic activity in mice bearing TNBC. 相关产品:Rapamycin | MG-132 | Cycloh...
TBHQ powder was directly mixed with the animal food powder at a ratio of 1% (w/w) as described previously. The efficacy of this protocol for TBHQ treatment in vivo has also been validated by other groups. TBHQ treatment was continued for 4 weeks after the TAC surgery [3]. 别名 特丁基对...
溶液配制5mg加入1.84ml DMSO,或者每2.71mg加入1ml DMSO,配制成10mM溶液。SC5498-10mM用DMSO配制。 生物信息: 产品描述Spautin-1是一种有效的特异性autophagy抑制剂,抑制USP10和USP13的去泛素化活性,IC50为~0.6-0.7μM。 信号通路Autophagy 靶点USP10USP10USP13-- ...
Dysregula- tion of the autophagic pathways has been observed in the brains of PD patients or in animal models of PD, and a number of PD-associated proteins, such as -synuclein, Parkin and PINK 1, were found to involve in autophagy, suggesting a link between autophagy and pathogenesis of ...
Westernblotting检测海马自噬体标记物LC-3、溶酶体酶CathepsinD、自噬信号通路中pmTOR/mTOR和beclin-1的表达。【结果】雷帕霉素可不同程度改善apoE/5XFAD转基因小鼠视空间学习记忆能力,以6月龄apoE3/5XFAD、apoE4/5XFAD组改善最为明显。雷帕霉素可减少不同月龄、不同亚型apoE/5XFAD转基因小鼠海马自噬小体内电子致密...
Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) 是一种合成抗疟疾剂,有效抑制SARS-CoV-2感染,也抑制 Toll 样受体 7/9 信号传导。 AutophagyParasiteSARS-CoVTLR ¥ 136 现货 规格 数量 客户已引用 Paeonol ...