2. How can the findings regarding phytochemical effects on efferocytosis and autophagy be translated into clinical practice for treating autoimmune and inflammatory disorders, and what specific clinical trials are needed to evaluate their efficacy? 3. What are the potential synergistic effects of combining...
2. How can the findings regarding phytochemical effects on efferocytosis and autophagy be translated into clinical practice for treating autoimmune and inflammatory disorders, and what specific clinical trials are needed to evaluate their efficacy? 3. What are the potential synergistic effects of combining...
the ARGs mainly functioned to regulate autophagy and to utilize autophagic mechanisms. Based on KEGG analysis, these genes were indicated to be mainly involved in signaling pathways related to autophagy-animal. Moreover, we added unbiased GO-BP and ...
In vivo analysis Southern Medical University Animal Center (Guang- zhou, China) provided the SD rats (n = 6, weight = 250 g). All experiments associated with animals were approved by and conducted in accordance with the regulations of the China National Ethics Committee on Animal ...
These nanoparticles were found to be suitable for intra-articular administration owing to their size, high encapsulation efficiency, and sustained release of rapamycin, resulting in positive therapeutic effects on local articular joint inflammation in an animal model of osteoarthritis. As a novel ...
N. Chowdhury, S. Chaudhry, N. Hall, G. Olverson, Q.J. Zhang, T. Mandal, S. Dash, A. Kundu Targeted delivery of doxorubicin liposomes for Her-2+ breast cancer treatment AAPS PharmSciTech, 21 (6) (2020), p. 202 View in ScopusGoogle Scholar [166] Y. Zhang, J. He, L. Shen,...
Given that only primates present a macula per se, there is no small animal model that fully recapitulates the disease (Soundara Pandi et al., 2021). Because AMD is characterized by primary RPE degeneration, the main in vitro model used is the ARPE-19 cell line, derived from the RPE of ...
Kevin N Dalby1940, Luisa Dalla Valle1822, Guillaume Dalmasso1340, Marcello D'Amelio557, Markus Damme188, Arlette Darfeuille-Michaud1340, Catherine Dargemont950, Victor M Darley-Usmar1433, Srinivasan Dasarathy205, Biplab Dasgupta202, Srikanta Dash1254, Crispin R Dass242, Hazel Marie Davey8, Leste...
All procedures were approved by the national authorities responsible for animal experiments in Luxembourg. Immunohistochemistry For mouse-specific CD31 staining cryostat sections (10 μm) of flash-frozen brains were fixed in ice-cold acetone and acetone : chloroform (1 : 1) for 5 min...
Ctr, n = 6 and Elig, n = 5 biologically independent animals, each dot is one animal. Data are presented as mean values ± SEM. Exact p-values are depicted in the figure. Statistical analysis was performed using unpaired two-tailed Student’s t-test for b–g and i–n. ...