N. Chowdhury, S. Chaudhry, N. Hall, G. Olverson, Q.J. Zhang, T. Mandal, S. Dash, A. Kundu Targeted delivery of doxorubicin liposomes for Her-2+ breast cancer treatment AAPS PharmSciTech, 21 (6) (2020), p. 202 View in ScopusGoogle Scholar [166] Y. Zhang, J. He, L. Shen,...
These nanoparticles were found to be suitable for intra-articular administration owing to their size, high encapsulation efficiency, and sustained release of rapamycin, resulting in positive therapeutic effects on local articular joint inflammation in an animal model of osteoarthritis. As a novel ...
2. How can the findings regarding phytochemical effects on efferocytosis and autophagy be translated into clinical practice for treating autoimmune and inflammatory disorders, and what specific clinical trials are needed to evaluate their efficacy? 3. What are the potential synergistic effects of combining...
the ARGs mainly functioned to regulate autophagy and to utilize autophagic mechanisms. Based on KEGG analysis, these genes were indicated to be mainly involved in signaling pathways related to autophagy-animal. Moreover, we added unbiased GO-BP and ...
and protein level changes confirmed by immunoblotting (see Supplementary Fig.3c).g,hMolecular functions of mRNAs whose ribosome occupancy isgincreased (p < 0.01,n = 36 significant genes) orhdecreased (p < 0.005,n = 60 significant genes) inAtg12KOcells versusAtg12f/fcells in...
Given that only primates present a macula per se, there is no small animal model that fully recapitulates the disease (Soundara Pandi et al., 2021). Because AMD is characterized by primary RPE degeneration, the main in vitro model used is the ARPE-19 cell line, derived from the RPE of ...
Retinitis pigmentosa is a group of hereditary retinal dystrophies that normally result in photoreceptor cell death and vision loss both in animal models and in affected patients. The rd10 mouse, which carries a missense mutation in the P... N Rodríguez-Muela,AM Hernández-Pinto,A Serrano-Puebla...
Kevin N Dalby1940, Luisa Dalla Valle1822, Guillaume Dalmasso1340, Marcello D'Amelio557, Markus Damme188, Arlette Darfeuille-Michaud1340, Catherine Dargemont950, Victor M Darley-Usmar1433, Srinivasan Dasarathy205, Biplab Dasgupta202, Srikanta Dash1254, Crispin R Dass242, Hazel Marie Davey8, Leste...
All procedures were approved by the national authorities responsible for animal experiments in Luxembourg. Immunohistochemistry For mouse-specific CD31 staining cryostat sections (10 μm) of flash-frozen brains were fixed in ice-cold acetone and acetone : chloroform (1 : 1) for 5 min...
Autophagy promotes protein degradation, and therefore has been proposed to maintain amino acid pools to sustain protein synthesis during metabolic stress. To date, how autophagy influences the protein synthesis landscape in mammalian cells remains unclea