73. Ding L, Spencer A, Morita K, Han M. The developmental timing regulator AIN-1 interacts with miRISCs and may target the Autophagy in animal development 917 argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans. Mol Cell. 2005;19:437–47. 74. Zhang L, Ding L, Cheung TH,...
animal virusesimmune escapeThe endoplasmic reticulum (ER) is a unique organelle responsible for protein synthesis and processing, lipid synthesis in eukaryotic cells, and the replication of many animal viruses isclosely related to ER. A considerable number of viral proteins are synthesised during viral...
The creation and analysis of transgenic and knockout animal models will help to understand the evolu- tionarily-acquired complexity of autophagy-mediated pro- cesses in mammals. Some gene (beclin-1, ATG5, and ATG7) knockout mice have already been used in experiments to explore the functions ...
In the further animal experiments, to investigate the effect of TFEB activation on adenine-induced CKD, mice were randomly divided into 3 groups, a third of the mice fed with normal diet and two third of the mice fed with adeine diet for 6 weeks. Among them, a half of mice which fed...
Seven-week-old CD-1® mice were bought from the Beijing Vital River Experimental Animals Centre (Beijing, China) and were raised at the department of animal experiments under standard housing conditions. The Laboratory Animal Care and Use Committee of the Institute of Zoology approved this researc...
Then, 1 μl of Annexin V-FITC and 2 ul of propidium iodide (PI) were added and the cells were incubated for 30 min in a humidified incubator at 37 °C and 5% CO2. Following incubation, the cells were centrifuged at 300 × g for 5 min and the supernatant was removed. The ...
Autophagy is closely related to aging, studies have suggested that it decreased in elderly animal models, and longevity is prolonged by genetic manipulation to increase autophagy [14, 15]. Autophagy is also involved in anti-aging function [11, 12]. Therefore, the changes in the autophagy of YO...
Methods Streptomycesspp. isolation, identification, and assessment of antifungal activity In order to isolateStreptomycesspp., different wheat (Triticum aestivumL., Jimai 22) tissues (including spikelets, stem, leaves, and root), rhizosphere soil samples, and soil samples (soil samples were collected...
Beclin 1-indepent Unknown Neurodegenerative disease models Reduction of polyglutamine and polyalanine aggregation[45]; Ameliorates polyglutamine aggregates and toxicity in animal models[46]; Alpha-synuclein degradation[47]; Ameliorates cognitive deficits and reduces amyloid-beta AD mouse model of Alzheimer'...
Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease. Neuron 60, 247–257 (2008). Article CAS PubMed PubMed Central Google Scholar Spencer, B. et al. Beclin 1 gene transfer activates autophagy and ameliorates the...