急性发作的机制之一,而自噬功能再度活化是急性痛风性关节炎自发缓解的机制.3.Beclin1,ATG16,ATG12,ATG5在完成自噬体的启动与延伸后,可能通过泛素化方式被自噬溶酶体降解,也可能是被相应microRNAs调控的结果,尚待进一步研究.4.Beclin1,ATG16L1,ATG5可能参与了 AG患者发病机制中的炎症调节,而且ATG16L1还可能参与了 ...
Toward the function of mammalian ATG12–ATG5-ATG16L1 complex in autophagy and related processesATG16L1Amphipathic helixGABARAPLAPLC3autophagyendosomelipidationmembraneThe machinery that decorates autophagic membranes with lipid-conjugated LC3/GABARAP is not yet fully understood. We recently reported the ...
Autophagy is critical for maintaining cellular homeostasis during times of stress, and is thought to play important roles in both tumorigenesis and tumor cell survival. Formation of autophagosomes, which mediate delivery of cytoplasmic cargo to lysosomes
RNAi-mediated silencing of Atg5, Atg12, and Atg16L1, which promote autophagophore expansion and LC3 membrane conjugation, interfered with viral core/nucleocapsid (NC) formation/stability and strongly diminished virus yields. Concomitantly, core/NC membrane association and their sorting to envelope-...
深入研究自噬基因共轭复合体ATG12-ATG5-ATG16L1在克罗恩病中的致病易感性 目的:全基因组关联研究(GWAS)揭示ATG16L1是CD的易感基因.而ATG12-ATG5-ATG16L1共轭复合体是自噬信号通路中一个关键性节点.本研究拟进一步深入探讨ATG12和ATG5是否与CD发病相关,以及三个自噬体基因是否具有协同作用.方法:除已报道的ATG16L1...
Figure 2. Interaction of Atg16L1 with WIPI2 Requires 207–242, a Domain Not Functionally Conserved in Atg16L2 (A) Scheme of mouse Atg16L1 and deletion mutants showing the N-terminal Atg5 interacting domain (white box), a coiled-coil domain (black box), and a WD propeller-repeat domain...
Vesicle formation requires the conjugation of the two ubiquitin-fold polypeptides ATG8 and ATG12 to phosphatidylethanolamine and the ATG5 protein, respectively. Using Arabidopsis thaliana mutants affecting the ATG5 target or the ATG7 E1 required to initiate ligation of both ATG8 and ATG12, we ...
ATG5 Polyclonal antibody 10181-2-AP ATG16L1 Polyclonal antibody 19812-1-AP ATG3 Polyclonal antibody 11262-2-AP ATG7 Polyclonal antibody 10088-2-AP GABARAP Polyclonal antibody 18723-1-AP GABARAPL1 Polyclonal antibody 11010-1-AP LC3B-Specific Polyclonal antibody 18725-1-AP LC3A/B Monoclonal antibody...
Yuan Gao1, Yanquan Wei1, Xiangtao Liu1, Ying Liao*,3, Huichen Guo*,1 and Shiqi Sun*,1 Autophagy-related protein ATG5-ATG12 is an essential complex for the autophagophore elongation in autophagy, which has been reported to be involved in foot-and-mouth disease virus (FMDV) replication...
TECPR1ATG16L1 is an essential component of the Atg8-family protein conjugation machinery, providing membrane targeting for the ATG12-ATG5 conjugate. Recently, we identified an alternative E3-like complex that functions independently of ATG16L1. This complex utilizes the autophagosome-lysosome tethering...