Xu, and J. Debnath, "Loss of Atg12, but not Atg5, in pro- opiomelanocortin neurons exacerbates diet-induced obesity", Autophagy, vol. 11, no. 1, pp. 145-154, 2015.Malhotra, R., Warne, J.P., Salas, E., Xu, A.W., and Debnath, J. (2015). Loss of Atg12, but not Atg5, ...
ATG12 increased cell apoptosis of HepG2.2.15 cells but not HepG2 cells under starvation conditions. These results suggest that ATG5-ATG12 proteins are important for the survival of HBV-associated HCC during states of limited tumor nutrients. The inhibition of ATG12 might be a good target for ...
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The aforementioned background diverted us to conduct exon mutation analysis for ATG5, ATG12, and ATG9B genes of colorectal cancer patients who were receiving neoadjuvant RT. Peripheral blood DNA from different time points (before/middle/after RT) of the same patients was isolated and most tandem...
Formation of autophagosomes, which mediate delivery of cytoplasmic cargo to lysosomes, requires multiple autophagy-related (ATG) protein complexes, including the ATG12–ATG5-ATG16L1 complex. Herein, we report that a molecular ATG5 “conjugation switch”, comprised of competing ATG12 and ubiquitin ...
Atg12–Atg5–Atg16 ComplexConjugasePhosphatidylethanolaminePre-Autophagosomal Structure (PASUbiquitinationAtg5 is covalently modified with Atg12 via reactions that are similar to ubiquitination, and it noncovalently interacts with Atg16. Formation of the Atg12-Atg5-Atg16 complex is essential for its E3-...
Yuan Gao1, Yanquan Wei1, Xiangtao Liu1, Ying Liao*,3, Huichen Guo*,1 and Shiqi Sun*,1 Autophagy-related protein ATG5-ATG12 is an essential complex for the autophagophore elongation in autophagy, which has been reported to be involved in foot-and-mouth disease virus (FMDV) replication...
Two autophagy-related ubiquitin-like systems have unique features: the E2 enzyme Atg3 conjugates the ubiquitin-like protein Atg8 to the lipid phosphatidylethanolamine, and the other ubiquitin-like protein conjugate Atg12–Atg5 promotes that conjugase activity of Atg3. Here, we elucidate the mode of...
Remarkably, we demonstrate that TECPR1 plays a crucial function in autophagosome maturation and promotes autophagosome-lysosome fusion by associating with both the Atg12-Atg5 conjugate and PtdIns(3)P. Through this study, we have uncovered a previously unknown critical function of the Atg12-Atg5-TEC...
HBV gained access to Atg5-12/16L1 via interaction of its core protein with the Atg12 moiety of the complex. In contrast, subsequent autophagosome maturation and closure events were unnecessary for HBV replication, as evidenced by inhibition of Atg8/LC3 conjugation. Interfering the HBV/Atg12 ...